PON1 polymorphisms can predict generalized anxiety and depressed mood in patients with multiple chemical sensitivity

Gabriele Sani, Maurizio Pompili, Giuseppe Gentile, Alessio Mosca, Antonio Del Casale, Marina Borro, Giovanna Gentile, Leda Marina Pomes, Alessio Padovano, Federica Fiaschè, Vito Pinzone, Chiara Rapinesi, Teodolinda Zoppi, Roberto Brugnoli, Georgios Demetrios Kotzalidis, Paolo Girardi, Stefano Ferracuti, Maurizio Simmaco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Background: Multiple chemical sensitivity (MCS) is a chronic condition with somatic, cognitive and affective symptoms that follow contact with chemical agents at usually non toxic concentrations. We aimed to assess the role of genetic polymorphisms involved in oxidative stress on anxiety and depression in MCS. Materials & methods: Our study investigated the CAT rs1001179, MPO rs2333227, PON1 rs662 and PON1 rs705379 polymorphisms in MCS. Results: The AG genotype of the PON1 rs662 and the TT and CT genotypes of the PON1 rs705379 were involved in anxiety and depression. Discussion: These results are in line with existing evidence of PON1 involvement in MCS and suggest a further role of this gene in the exhibition of anxiety and depression in this disease.
Lingua originaleEnglish
pagine (da-a)255-267
Numero di pagine13
RivistaPersonalized Medicine
Volume18
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • anxiety
  • depression
  • genomics
  • hyperosmia
  • multiple chemical sensitivity
  • oxidative stress
  • paraoxonase

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