Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus

D Frezza; Barbara Tolusso; V Giambra; Elisa Gremese; M Marchini; M Nowik; E Serone; P D'Addabbo; C Mattioli; S Canestri; L Petricca; G D'Antona; Bk Birshtein; R Scorza; Gianfranco Ferraccioli

doi:10.1136/ard.2010.147025

Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus

D Frezza^*
, Barbara Tolusso
, V Giambra
, Elisa Gremese
, M Marchini
, M Nowik
, E Serone
, P D'Addabbo
, C Mattioli
, S Canestri
, L Petricca
, G D'Antona
, Bk Birshtein
, R Scorza
, Gianfranco Ferraccioli

^*Autore corrispondente per questo lavoro

Facoltà di Medicina e Chirurgia "A.Gemelli"

Risultato della ricerca: Contributo in rivista › Articolo

23 Citazioni (Scopus)

Abstract

To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.

Lingua originale	Inglese
pagine (da-a)	1309-1315
Numero di pagine	7
Rivista	EARD
Volume	71
Numero di pubblicazione	8
DOI	https://doi.org/10.1136/ard.2010.147025
Stato di pubblicazione	Pubblicato - 2012

All Science Journal Classification (ASJC) codes

Reumatologia
Immunologia e Allergia
Immunologia
Biochimica, Genetica, Biologia Molecolare Generali

Keywords

Genetic
Immunoglobulin Heavy Chains
Lupus Erythematosus
Polymorphism
Systemic

Accesso al documento

10.1136/ard.2010.147025

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abstract = "To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.",

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AU - Frezza, D

AU - Tolusso, Barbara

AU - Giambra, V

AU - Gremese, Elisa

AU - Marchini, M

AU - Nowik, M

AU - Serone, E

AU - D'Addabbo, P

AU - Mattioli, C

AU - Canestri, S

AU - Petricca, L

AU - D'Antona, G

AU - Birshtein, Bk

AU - Scorza, R

AU - Ferraccioli, Gianfranco

PY - 2012

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AB - To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1.

KW - Genetic

KW - Immunoglobulin Heavy Chains

KW - Lupus Erythematosus

KW - Polymorphism

KW - Systemic

KW - Genetic

KW - Immunoglobulin Heavy Chains

KW - Lupus Erythematosus

KW - Polymorphism

KW - Systemic

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U2 - 10.1136/ard.2010.147025

DO - 10.1136/ard.2010.147025

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SP - 1309

EP - 1315

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Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus

Abstract

All Science Journal Classification (ASJC) codes

Keywords

Accesso al documento

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