Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes

Francesco D'Alo', Livio Pagano, Stefan Hohaus, Emiliano Fabiani, Alessandra Scardocci, Mariangela Greco, Annalisa Di Ruscio, Marianna Criscuolo, Luana Fianchi, Giuseppe Leone, Maria Teresa Voso

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

21 Citazioni (Scopus)

Abstract

The genetic background may modify the individual's risk of developing cancer. We performed a case-control study to test the impact of genomic polymorphisms of 9 genes involved in xenobiotics detoxification and DNA repair in myelodysplastic syndromes (MDS). Frequencies of polymorphic variants of RAD51, XRCC3, NQO1, GSTA1, GSTM1, GSTT1, CYP3A4 and XPD enzymes were similar in patients and controls. On the other hand, the GSTP1-105Val allele was associated to an increased risk of MDS (O.R. 1.66; p=0.04) and to higher probability of overall survival in the low/intermediate-1 IPSS risk group (p=0.008). The GSTP1-Ile105Val polymorphism is likely to influence MDS risk and prognosis.
Lingua originaleEnglish
pagine (da-a)1068-1071
Numero di pagine4
RivistaLeukemia Research
Volume2009
Stato di pubblicazionePubblicato - 2009

Keywords

  • DNA repair
  • Detoxiifcation enzymes
  • Myelodysplastic syndromes
  • Polymorphism

Fingerprint

Entra nei temi di ricerca di 'Polymorphisms of detoxification and DNA repair enzymes in myelodyplastic syndromes'. Insieme formano una fingerprint unica.

Cita questo