TY - JOUR
T1 - Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity
AU - Basso, Michele
AU - Modoni, Anna
AU - Spada, Danilo
AU - Cassano, Alessandra
AU - Schinzari, Giovanni
AU - Lo Monaco, Mauro
AU - Quaranta, Davide
AU - Tonali, Pa
AU - Barone, Carlo Antonio
PY - 2011
Y1 - 2011
N2 - There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 gene polymorphism may influence the development of acute nerve hyperexcitability in oxaliplatin-treated patients.
AB - There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 gene polymorphism may influence the development of acute nerve hyperexcitability in oxaliplatin-treated patients.
KW - Aged
KW - Amino Acid Motifs
KW - Antineoplastic Agents
KW - Biliary Tract Neoplasms
KW - Colorectal Neoplasms
KW - Electromyography
KW - Female
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Humans
KW - Male
KW - Neoplasms
KW - Neural Conduction
KW - Neurologic Examination
KW - Organoplatinum Compounds
KW - Pancreatic Neoplasms
KW - Peripheral Nervous System Diseases
KW - Polymorphism, Genetic
KW - Small-Conductance Calcium-Activated Potassium Channels
KW - Stomach Neoplasms
KW - Aged
KW - Amino Acid Motifs
KW - Antineoplastic Agents
KW - Biliary Tract Neoplasms
KW - Colorectal Neoplasms
KW - Electromyography
KW - Female
KW - Genetic Association Studies
KW - Genetic Predisposition to Disease
KW - Humans
KW - Male
KW - Neoplasms
KW - Neural Conduction
KW - Neurologic Examination
KW - Organoplatinum Compounds
KW - Pancreatic Neoplasms
KW - Peripheral Nervous System Diseases
KW - Polymorphism, Genetic
KW - Small-Conductance Calcium-Activated Potassium Channels
KW - Stomach Neoplasms
UR - http://hdl.handle.net/10807/29530
U2 - 10.1007/s00280-010-1466-y
DO - 10.1007/s00280-010-1466-y
M3 - Article
SN - 0344-5704
VL - 67
SP - 1179
EP - 1187
JO - Cancer Chemotherapy and Pharmacology
JF - Cancer Chemotherapy and Pharmacology
ER -