Polymorphism of CAG motif of SK3 gene is associated with acute oxaliplatin neurotoxicity

Alessandra Cassano, Michele Basso, Anna Modoni, Danilo Spada, Giovanni Schinzari, Mauro Lo Monaco, Davide Quaranta, Carlo Antonio Barone, Pa Tonali

Risultato della ricerca: Contributo in rivistaArticolo in rivista

18 Citazioni (Scopus)

Abstract

There is no agreement on which channel is involved in oxaliplatin neurotoxicity, most investigators favouring voltage-gated sodium channels. However, the small conductance Ca(++) activated K(+) channels, encoded by the SK1-3 genes, are also involved in membrane excitability, playing a role in after-hyperpolarization at the motor nerve terminal. As the SK3 gene is characterized in Caucasians by a highly polymorphic CAG motif within the exon 1, we hypothesize that SK3 gene polymorphism may influence the development of acute nerve hyperexcitability in oxaliplatin-treated patients.
Lingua originaleEnglish
pagine (da-a)1179-1187
Numero di pagine9
RivistaCancer Chemotherapy and Pharmacology
Volume67
DOI
Stato di pubblicazionePubblicato - 2011

Keywords

  • Aged
  • Amino Acid Motifs
  • Antineoplastic Agents
  • Biliary Tract Neoplasms
  • Colorectal Neoplasms
  • Electromyography
  • Female
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Humans
  • Male
  • Neoplasms
  • Neural Conduction
  • Neurologic Examination
  • Organoplatinum Compounds
  • Pancreatic Neoplasms
  • Peripheral Nervous System Diseases
  • Polymorphism, Genetic
  • Small-Conductance Calcium-Activated Potassium Channels
  • Stomach Neoplasms

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