TY - JOUR
T1 - Polymorphism C in the serotonin 1 transporter gene in depression-free elderly patients with vascular dementia
AU - Seripa, D
AU - MG, Matera
AU - D'Onofrio, G
AU - Sancarlo, D
AU - Bizzarro, A
AU - Cascavilla, L
AU - Paris, F
AU - Gravina, C
AU - Bonghi, L
AU - Capurso, C
AU - Solfrizzi, V
AU - Daniele, Antonio
AU - Masullo, C
AU - Panza, F
AU - Pilotto, A.
PY - 2010
Y1 - 2010
N2 - BACKGROUND:\r\n\r\nGenotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD).\r\nAIMS:\r\n\r\nTo evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD.\r\nMETHODS:\r\n\r\nThe analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients.\r\nRESULTS:\r\n\r\nNo important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made.\r\nCONCLUSION:\r\n\r\nOur findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.
AB - BACKGROUND:\r\n\r\nGenotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD).\r\nAIMS:\r\n\r\nTo evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD.\r\nMETHODS:\r\n\r\nThe analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients.\r\nRESULTS:\r\n\r\nNo important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made.\r\nCONCLUSION:\r\n\r\nOur findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.
KW - Risk Factors
KW - Serotoni 1 transporter gene polymorphism
KW - Vascular Dementia
KW - Risk Factors
KW - Serotoni 1 transporter gene polymorphism
KW - Vascular Dementia
UR - https://publicatt.unicatt.it/handle/10807/6925
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=77952505261&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=77952505261&origin=inward
U2 - 10.1159/000275670
DO - 10.1159/000275670
M3 - Article
SN - 1420-8008
SP - 424
EP - 431
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
IS - 29
ER -