Abstract
BACKGROUND:
Genotypes of the solute carrier family 6 (neurotransmitter transporter, serotonin) member 4 (SLC6A4) have been variously associated with depression, obsessive-compulsive disorder, memory impairment, and anxiety. Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD).
AIMS:
To evaluate the possible involvement of different SLC6A4 genotypes/haplotypes in VaD.
METHODS:
The analysis of the 3 markers rs3813034, rs140701 and rs4795541 spanning the SLC6A4 locus was made in 541 consecutive patients clinically diagnosed as having VaD (n = 372) or no cognitive impairment (n = 169) attending a geriatric ward. A community-dwelling sample of 353 healthy subjects, as a reference for the genetic frequencies in the recruitment area, was also included in the study. All patients and subjects were free from any symptoms of depression, obsessive-compulsive disorder and anxiety. A complete neuroimaging documentation was available for all patients.
RESULTS:
No important differences were observed in genotype distribution across the study groups. Similarly, no important differences were observed in haplotype distribution when a 3-point analysis was made.
CONCLUSION:
Our findings suggest that polymorphism C in the promoter region of the SLC6A4 gene plays a minor role, if any, in the pathogenesis of VaD.
Lingua originale | English |
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pagine (da-a) | 424-431 |
Numero di pagine | 8 |
Rivista | Dementia and Geriatric Cognitive Disorders |
DOI | |
Stato di pubblicazione | Pubblicato - 2010 |
Keywords
- Risk Factors
- Serotoni 1 transporter gene polymorphism
- Vascular Dementia