Polyclonal serum-free light chains elevation in HIV-infected patients

Michele Bibas; Patrizia Lorenzini; Alessandro Cozzi-Lepri; Andrea Calcagno; Simona Di Giambenedetto; Andrea Costantini; Antonella Castagna; Vinicio Manfrin; Antonella D. Monforte; Andrea Antinori

doi:10.1097/QAD.0b013e328358d54b

Polyclonal serum-free light chains elevation in HIV-infected patients

Michele Bibas, Patrizia Lorenzini, Alessandro Cozzi-Lepri, Andrea Calcagno, Simona Di Giambenedetto, Andrea Costantini, Antonella Castagna, Vinicio Manfrin, Antonella D. Monforte, Andrea Antinori

Risultato della ricerca: Contributo in rivista › Articolo in rivista

9 Citazioni (Scopus)

Abstract

We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.

Lingua originale	English
pagine (da-a)	2107-2110
Numero di pagine	4
Rivista	AIDS
Volume	26
DOI	https://doi.org/10.1097/QAD.0b013e328358d54b
Stato di pubblicazione	Pubblicato - 2012

Keywords

Polyclonal light chains , HIV

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abstract = "We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.",

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author = "Michele Bibas and Patrizia Lorenzini and Alessandro Cozzi-Lepri and Andrea Calcagno and {Di Giambenedetto}, Simona and Andrea Costantini and Antonella Castagna and Vinicio Manfrin and Monforte, {Antonella D.} and Andrea Antinori",

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doi = "10.1097/QAD.0b013e328358d54b",

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T1 - Polyclonal serum-free light chains elevation in HIV-infected patients

AU - Bibas, Michele

AU - Lorenzini, Patrizia

AU - Cozzi-Lepri, Alessandro

AU - Calcagno, Andrea

AU - Di Giambenedetto, Simona

AU - Costantini, Andrea

AU - Castagna, Antonella

AU - Manfrin, Vinicio

AU - Monforte, Antonella D.

AU - Antinori, Andrea

PY - 2012

Y1 - 2012

N2 - We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.

AB - We investigated the association between polyclonal serum-free light chains and prognostic biomarkers routinely used in the setting of HIV infection. For this purpose serum samples of 182 HIV-infected patients from the Italian Cohort of Antiretroviral Naive Patients foundation cohort were analysed. We found that polyclonal serum free light chains above the upper normal limit are strongly correlated in HIV-infected patients with advancing age, shorter time of undetectable HIV viremia, higher viral load and with lower CD4 cell count at sample.

KW - Polyclonal light chains , HIV

UR - http://hdl.handle.net/10807/39874

U2 - 10.1097/QAD.0b013e328358d54b

DO - 10.1097/QAD.0b013e328358d54b

M3 - Article

SN - 0269-9370

VL - 26

SP - 2107

EP - 2110

JO - AIDS

JF - AIDS

ER -

Polyclonal serum-free light chains elevation in HIV-infected patients

Abstract

Keywords

OSS delle Nazioni Unite

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