Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists

Carlo Furlan; Stefano Arcangeli; Michele Avanzo; Maria A. Mirri; Maria Alessandra Mirri; Fernando Munoz; Stefania Giudici; Antonio Perrone; Dante Amelio; Luigi Tomio; Loredana Draghini; Aniko M. Deli; Giovanni Pavanato; Francesca M. Giuliano; Antonio Pontoriero; Patrizia Ciammella; Pierina Navarria; Alberto Iannalfi; Michela Buglione; Cesare Guida; Silvia Cammelli; Vincenzo Iorio; Massimo Cardinali; Domenico Genovesi; Lucia Barsacchi; Mario Balducci; Rita Bagnoli; Franco Berti; Giampaolo Montesi; Francesco Pasqualetti; Paolo Bonome; Riccardo Santoni; Daniela Doino; Patrizia Schirru; Valentina Pinzi; Valentina Borzillo; Fabio Ferrarese; Marica Ferro; Luigi De Cicco; Marco Krengli; Silvia Scoccianti; Vittorio Donato

doi:10.5301/tj.5000615

Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists

Carlo Furlan, Stefano Arcangeli, Michele Avanzo, Maria A. Mirri, Maria Alessandra Mirri, Fernando Munoz, Stefania Giudici, Antonio Perrone, Dante Amelio, Luigi Tomio, Loredana Draghini, Aniko M. Deli, Giovanni Pavanato, Francesca M. Giuliano, Antonio Pontoriero, Patrizia Ciammella, Pierina Navarria, Alberto Iannalfi, Michela Buglione, Cesare GuidaSilvia Cammelli, Vincenzo Iorio, Massimo Cardinali, Domenico Genovesi, Lucia Barsacchi, Mario Balducci, Rita Bagnoli, Franco Berti, Giampaolo Montesi, Francesco Pasqualetti, Paolo Bonome, Riccardo Santoni, Daniela Doino, Patrizia Schirru, Valentina Pinzi, Valentina Borzillo, Fabio Ferrarese, Marica Ferro, Luigi De Cicco, Marco Krengli, Silvia Scoccianti, Vittorio Donato

Università Cattolica del Sacro Cuore

Risultato della ricerca: Contributo in rivista › Articolo in rivista

Abstract

PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.

Lingua originale	English
pagine (da-a)	0-0
Numero di pagine	1
Rivista	Tumori
Volume	2017
DOI	https://doi.org/10.5301/tj.5000615
Stato di pubblicazione	Pubblicato - 2017

Keywords

Reirradiation, gliomas (HGG)

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10.5301/tj.5000615

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Furlan, C., Arcangeli, S., Avanzo, M., Mirri, M. A., Mirri, M. A., Munoz, F., Giudici, S., Perrone, A., Amelio, D., Tomio, L., Draghini, L., Deli, A. M., Pavanato, G., Giuliano, F. M., Pontoriero, A., Ciammella, P., Navarria, P., Iannalfi, A., Buglione, M., ... Donato, V. (2017). Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists. Tumori, 2017, 0-0. https://doi.org/10.5301/tj.5000615

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title = "Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists",

abstract = "PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.",

keywords = "Reirradiation, gliomas (HGG), Reirradiation, gliomas (HGG)",

author = "Carlo Furlan and Stefano Arcangeli and Michele Avanzo and Mirri, {Maria A.} and Mirri, {Maria Alessandra} and Fernando Munoz and Stefania Giudici and Antonio Perrone and Dante Amelio and Luigi Tomio and Loredana Draghini and Deli, {Aniko M.} and Giovanni Pavanato and Giuliano, {Francesca M.} and Antonio Pontoriero and Patrizia Ciammella and Pierina Navarria and Alberto Iannalfi and Michela Buglione and Cesare Guida and Silvia Cammelli and Vincenzo Iorio and Massimo Cardinali and Domenico Genovesi and Lucia Barsacchi and Mario Balducci and Rita Bagnoli and Franco Berti and Giampaolo Montesi and Francesco Pasqualetti and Paolo Bonome and Riccardo Santoni and Daniela Doino and Patrizia Schirru and Valentina Pinzi and Valentina Borzillo and Fabio Ferrarese and Marica Ferro and {De Cicco}, Luigi and Marco Krengli and Silvia Scoccianti and Vittorio Donato",

year = "2017",

doi = "10.5301/tj.5000615",

language = "English",

volume = "2017",

pages = "0--0",

journal = "Tumori",

issn = "0300-8916",

publisher = "Wichtig Publishing Srl",

}

Furlan, C, Arcangeli, S, Avanzo, M, Mirri, MA, Mirri, MA, Munoz, F, Giudici, S, Perrone, A, Amelio, D, Tomio, L, Draghini, L, Deli, AM, Pavanato, G, Giuliano, FM, Pontoriero, A, Ciammella, P, Navarria, P, Iannalfi, A, Buglione, M, Guida, C, Cammelli, S, Iorio, V, Cardinali, M, Genovesi, D, Barsacchi, L, Balducci, M, Bagnoli, R, Berti, F, Montesi, G, Pasqualetti, F, Bonome, P, Santoni, R, Doino, D, Schirru, P, Pinzi, V, Borzillo, V, Ferrarese, F, Ferro, M, De Cicco, L, Krengli, M, Scoccianti, S & Donato, V 2017, 'Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists', Tumori, vol. 2017, pagg. 0-0. https://doi.org/10.5301/tj.5000615

TY - JOUR

T1 - Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists

AU - Furlan, Carlo

AU - Arcangeli, Stefano

AU - Avanzo, Michele

AU - Mirri, Maria A.

AU - Mirri, Maria Alessandra

AU - Munoz, Fernando

AU - Giudici, Stefania

AU - Perrone, Antonio

AU - Amelio, Dante

AU - Tomio, Luigi

AU - Draghini, Loredana

AU - Deli, Aniko M.

AU - Pavanato, Giovanni

AU - Giuliano, Francesca M.

AU - Pontoriero, Antonio

AU - Ciammella, Patrizia

AU - Navarria, Pierina

AU - Iannalfi, Alberto

AU - Buglione, Michela

AU - Guida, Cesare

AU - Cammelli, Silvia

AU - Iorio, Vincenzo

AU - Cardinali, Massimo

AU - Genovesi, Domenico

AU - Barsacchi, Lucia

AU - Balducci, Mario

AU - Bagnoli, Rita

AU - Berti, Franco

AU - Montesi, Giampaolo

AU - Pasqualetti, Francesco

AU - Bonome, Paolo

AU - Santoni, Riccardo

AU - Doino, Daniela

AU - Schirru, Patrizia

AU - Pinzi, Valentina

AU - Borzillo, Valentina

AU - Ferrarese, Fabio

AU - Ferro, Marica

AU - De Cicco, Luigi

AU - Krengli, Marco

AU - Scoccianti, Silvia

AU - Donato, Vittorio

PY - 2017

Y1 - 2017

N2 - PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.

AB - PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.

KW - Reirradiation, gliomas (HGG)

UR - http://hdl.handle.net/10807/112735

U2 - 10.5301/tj.5000615

DO - 10.5301/tj.5000615

M3 - Article

SN - 0300-8916

VL - 2017

SP - 0

EP - 0

JO - Tumori

JF - Tumori

ER -

Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists

Abstract

Keywords

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