Policies for reirradiation of recurrent high-grade gliomas: a survey among Italian radiation oncologists

Mario Balducci, Stefano Arcangeli, Maria Alessandra Mirri, Marica Ferro, Carlo Furlan, Michele Avanzo, Maria A. Mirri, Fernando Munoz, Stefania Giudici, Antonio Perrone, Dante Amelio, Luigi Tomio, Loredana Draghini, Aniko M. Deli, Giovanni Pavanato, Francesca M. Giuliano, Antonio Pontoriero, Patrizia Ciammella, Pierina Navarria, Alberto IannalfiMichela Buglione, Cesare Guida, Silvia Cammelli, Vincenzo Iorio, Massimo Cardinali, Lucia Barsacchi, Rita Bagnoli, Franco Berti, Giampaolo Montesi, Francesco Pasqualetti, Paolo Bonome, Riccardo Santoni, Daniela Doino, Patrizia Schirru, Valentina Pinzi, Valentina Borzillo, Fabio Ferrarese, Luigi De Cicco, Marco Krengli, Silvia Scoccianti, Vittorio Donato

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

PURPOSE: To assess the contribution of Italian radiation oncologists in the current management of recurrent high-grade gliomas (HGG), focusing on a reirradiation (reRT) approach. METHODS: In 2015, the Reirradiation and the Central Nervous System Study Groups on behalf of the Italian Association of Radiation Oncology (AIRO) proposed a survey. All Italian radiation oncologists were individually invited to complete an online questionnaire regarding their clinical management of recurrent HGG, focusing on a reRT approach. RESULTS: A total of 37 of 210 questionnaires were returned (18% of all centers): 16 (43%) from nonacademic hospitals, 14 (38%) from academic hospitals, 5 (13%) from private institutions, and 2 (6%) from hadron therapy centers. The majority of responding centers (59%) treated ≤5 cases per year. Performance status at the time of recurrence, along with a target diameter <5 cm and an interval from primary radiation ≥6 months, were the prevalent predictive factors considered for reRT. Sixty percent of reirradiated patients had already received a salvage therapy, either chemotherapy (40%) or reoperation (20%). The most common approach for reRT was fractionated stereotactic radiotherapy to a mean (photon) dose of 41.6 Gy. CONCLUSIONS: Although there were wide variations in the clinical practice of reRT across the 37 centers, the core activities were reasonably consistent. These findings provide a basis for encouraging a national collaborative study to develop, implement, and monitor the use of reRT in this challenging clinical setting.
Lingua originaleEnglish
pagine (da-a)0-0
Numero di pagine1
RivistaTumori
Volume2017
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Reirradiation, gliomas (HGG)

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