Plexin A is a neuronal semaphorin receptor that controls axon guidance

Luca Tamagnone, Margaret L. Winberg, Jasprina N. Noordermeer, Paolo M. Comoglio, Melanie K. Spriggs, Marc Tessier-Lavigne, Corey S. Goodman

Risultato della ricerca: Contributo in rivistaArticolo in rivista

364 Citazioni (Scopus)

Abstract

The Semaphorins comprise a large family of secreted and transmembrane proteins, some of which function as repellents during axon guidance. Semaphorins fall into seven subclasses. Neuropilins are neuronal receptors for class III Semaphorins. In the immune system, VESPR, a member of the Plexin family, is a receptor for a viral-encoded Semaphorin. Here, we identify two Drosophila Plexins, both of which are expressed in the developing nervous system. We present evidence that Plexin A is a neuronal receptor for class I Semaphorins (Sema 1a and Sema 1b) and show that Plexin A controls motor and CNS axon guidance. Plexins, which themselves contain complete Semaphorin domains, may be both the ancestors of classical Semaphorins and binding partners for Semaphorins.
Lingua originaleEnglish
pagine (da-a)903-916
Numero di pagine14
RivistaCell
Volume95
DOI
Stato di pubblicazionePubblicato - 1998

Keywords

  • Biochemistry, Genetics and Molecular Biology (all)

Fingerprint

Entra nei temi di ricerca di 'Plexin A is a neuronal semaphorin receptor that controls axon guidance'. Insieme formano una fingerprint unica.

Cita questo