Platinum compounds and sodium metabolism in children with diencephalic glioma

Nadia Puma, Antonio Ruggiero, Maria Scalzone, Paola Coccia, Silvia Triarico, Giovanna Trombatore, Stefano Mastrangelo, Riccardo Riccardi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

3 Citazioni (Scopus)


In this brief report we have described eight children affected by optic pathway/hypothalamus gliomas and treated with carboplatin and/or cisplatin, which developed a derangement of sodium and water metabolism, due to diabetes insipidus (DI) or to syndrome of inappropriate antidiuretic hormone secretion (SIADH) after surgical resection. In four out of these eight patients the treatment with platinum compounds produced prolonged haematological toxicity and in five out of them it caused neurosensorial bilateral hypoacusia. In addition cisplatin worsened electrolytes disturbances. Hence children with DI or SIADH should be carefully monitored before, during and after the treatment with platinum compounds.
Lingua originaleEnglish
pagine (da-a)113-117
Numero di pagine5
RivistaJournal of Neuro-Oncology
Stato di pubblicazionePubblicato - 2013


  • diencephalic glioma
  • platinum compounds


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