Platelets: the point of interconnection among cancer, inflammation and cardiovascular diseases

Massimo Massetti, Filippo Crea, Massimiliano Camilli, Giulia Iannaccone, Giulia La Vecchia, Luigi Cappannoli, Roberto Scacciavillani, Nadia Aspromonte, Giorgio Minotti

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Introduction: The association between thrombosis, cancer and inflammation is well-established. Platelets play a major role in atherosclerosis, inflammation and immune response. Furthermore, growing evidence suggests that they are also significantly involved in tumor development and progression so that anti-platelet agents may prevent cancer and improve outcomes in oncological patients. In this review, we aimed at analyzing the relationship between platelets, cardiovascular diseases and cancer. A comprehensive study in the main educational platforms was performed and high-quality original articles and reviews were included. Areas covered: This review will focus on the role of platelets in cardiovascular disease and in cancer genesis and progression, analyzing their function as immune cells that link inflammation to thrombosis. Finally, it will examine the recent controversies on the use of anti-platelet agents as cancer medications, in particular the already known anti-tumor properties of aspirin, as well as the new perspectives regarding P2Y12 inhibitors. Expert opinion: Platelet-cancer crosstalk generates a vicious feed-back loop involving tumor cells and secreting molecules that activate platelets, which in turn promote cancer-associated inflammation, proliferation, spreading and immune system evasion. Therefore, platelets inhibition may represent an innovative therapeutical strategy offered to cancer patients, in the perspective of personalized medicine.
Lingua originaleEnglish
pagine (da-a)537-546
Numero di pagine10
RivistaExpert Review of Hematology
Volume14
DOI
Stato di pubblicazionePubblicato - 2021

Keywords

  • anti-platelet drugs
  • cancer
  • cardiovascular diseases
  • personalized medicine
  • Platelets
  • Neoplasms
  • Humans
  • Inflammation
  • Platelet Aggregation Inhibitors
  • Cardiovascular Diseases
  • Blood Platelets

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