Platelet-associated IgG in acute and chronic hepatic diseases.

Raffaele Landolfi, Giuseppe Leone, Giuseppe Fedeli, Sergio Storti, F Laghi, B. Bizzi

Risultato della ricerca: Contributo in rivistaArticolo in rivista


In order to investigate the role of an immune mechanism in the pathogenesis of thrombocytopenia in hepatic patients, we measured platelet associated IgG (PAIgG) in 84 patients with various hepatic diseases. Increased PAIgG levels were found in 84% of patients with chronic active hepatitis (mean 21.32 +/- 8.45 fg/platelet) and in 75% of those with cirrhosis with hepatitis (mean 17.3 +/- 11.2 fg/platelet). In these patients there was no significant correlation between PAIgG and platelet count. Increased PAIgG amounts were also observed in some patients with inactive cirrhosis (18%). Normal PAIgG values were found in all patients with acute viral hepatitis and chronic persistent hepatitis. An immunologic mechanism may play a role in the pathogenesis of thrombocytopenia in hepatic patients. Furthermore, measurement of PAIgG may have a great usefulness in the differential diagnosis of chronic hepatic diseases
Lingua originaleEnglish
pagine (da-a)417-422
Numero di pagine6
Stato di pubblicazionePubblicato - 1980




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