Platelet activation in obese women: role of inflammation and oxidant stress

Carlo Patrono, Giovanni Davì, Maria Teresa Guagnano, Giovanni Ciabattoni, Stefania Basili, Angela Falco, Marina Marinopiccoli, Michele Nutini, Sergio Sensi

Risultato della ricerca: Contributo in rivistaArticolo in rivista

467 Citazioni (Scopus)

Abstract

Abstract BACKGROUND: To investigate early events possibly related to the development of diabetic angiopathy, we examined whether 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha) formation, a marker of in vivo oxidant stress, is altered in different stages of type 1 diabetes (T1DM) and whether it correlates with the rate of thromboxane (TX) A2 biosynthesis, a marker of in vivo platelet activation. We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting. METHODS AND RESULTS: A cross-sectional study was performed in 23 insulin-treated patients aged <18 years with new-onset T1DM (<or=6 weeks, group A), matched for age and gender with 23 patients with stable disease (>1 year, group B). Urinary 8-iso-PGF2alpha and 11-dehydro-TXB2 were measured in all patients and in age- and gender-matched controls. Circulating interleukin-6 (IL-6), tumor necrosis factor-alpha, and C-reactive protein were also determined as markers of the inflammatory response. Fifteen of the 23 children in group A were reexamined after 12 months. Compared with either controls or group B, diabetic children in group A showed significantly higher levels of 8-iso-PGF2alpha, 11-dehydro-TXB2, IL-6, tumor necrosis factor-alpha, and C-reactive protein. Statistically significant correlations between IL-6 and both 8-iso-PGF2alpha (r=0.63, P<0.001) and 11-dehydro-TXB2 (r=0.51, P<0.01) were observed. The 15 patients reexamined after 1 year showed a significant reduction in lipid peroxidation and platelet activation (P<0.02 and P<0.001, respectively), consistent with reduced levels of IL-6 and tumor necrosis factor-alpha. CONCLUSIONS: These results demonstrate that enhanced lipid peroxidation and platelet activation represent early events in T1DM that are possibly related to an acute inflammatory response. These noninvasive indexes may help in further examining T1DM pathophysiology and monitoring pharmacological interventions to interfere with disease development and progression.
Lingua originaleEnglish
pagine (da-a)2008-2014
Numero di pagine7
RivistaJAMA
Volume288
Stato di pubblicazionePubblicato - 2002

Keywords

  • Adult
  • Blood Glucose
  • Body Mass Index
  • C-Reactive Protein
  • Cardiovascular Diseases
  • Cross-Sectional Studies
  • Diet, Reducing
  • Dinoprost
  • F2-Isoprostanes
  • Female
  • Humans
  • Inflammation
  • Insulin
  • Leptin
  • Linear Models
  • Lipid Peroxidation
  • Middle Aged
  • Obesity
  • Oxidative Stress
  • Platelet Aggregation
  • Risk Factors
  • Statistics, Nonparametric
  • Thromboxane B2
  • Weight Loss

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