Plasma protein corona reduces the haemolytic activity of graphene oxide nano and micro flakes

Massimiliano Papi, Gabriele Ciasca, Giuseppe Maulucci, Marco De Spirito, Maria Carmela Lauriola, Valentina Palmieri

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

38 Citazioni (Scopus)

Abstract

Intensive research on the bio-applications of graphene and its derivatives is leading to many technological applications. Graphene Oxide (GO), for its unique 2-D structure and its physical/chemical properties, has attracted increasing interest over the last few years in the fields of drug/gene delivery, biological imaging and antibacterial treatments. Together with these great potentials for biomedical applications, several aspects of graphene toxicity mechanisms including oxidative stress, cutting off intracellular metabolic routes and cell membrane rupture must be carefully evaluated. In this work we demonstrate that the GO flakes, able to disrupt the erythrocyte plasma membrane, greatly reduce their hemolytic activity after interacting with plasma proteins.
Lingua originaleEnglish
pagine (da-a)81638-81641
Numero di pagine4
RivistaRSC Advances
Volume5
DOI
Stato di pubblicazionePubblicato - 2015

Keywords

  • Graphene oxide

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