Placental transfer of phenobarbital: what is new?

Simonetta Frezza, Sergio Ferrazzani, Sara De Carolis, Costantino Romagnoli, Mp De Carolis, E D'Urzo, U Muzii, A Mezza

Risultato della ricerca: Contributo in rivistaArticolo in rivista

10 Citazioni (Scopus)

Abstract

The placental transfer of phenobarbital was investigated in 35 mother-infant pairs at birth. The drug was administered prenatally to the mothers for maternal epilepsy (group 1, n = 5), gestational hypertension and preeclampsia (group 2, n = 20) and prophylaxis of intraventricular hemorrhage in premature deliveries (group 3, n = 10). The phenobarbital levels in arterial cord blood were 100 +/- 2.8% in group 1, 89 +/- 21% in group 2 and 77 +/- 16% in group 3 with respect to the levels observed in the mothers. The most important factor influencing the transplacental passage was the duration of maternal treatment in the infant of group 1 (r = 0.80, p < 0.01), the gestational age in the infants of group 2 (r = 0.74, p < 0.01) and the arterial cord pH in the infants of group 3 (r = 0.89, p < 0.001).
Lingua originaleEnglish
pagine (da-a)19-26
Numero di pagine8
RivistaDevelopmental Pharmacology and Therapeutics
Volume19
Stato di pubblicazionePubblicato - 1992

Keywords

  • Blood Gas Analysis
  • Female
  • Fetal Blood
  • Humans
  • Hydrogen-Ion Concentration
  • Infant, Newborn
  • Phenobarbital
  • Placenta
  • Pregnancy

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