Pitfalls in the measurement of muscle mass: a need for a reference standard

Francesco Landi, Fanny Buckinx, Matteo Cesari, Roger A. Fielding, Marjolein Visser, Klaus Engelke, Stefania Maggi, Elaine Dennison, Nasser M. Al-Daghri, Sophie Allepaerts, Jurgen Bauer, Ivan Bautmans, Maria Luisa Brandi, Olivier Bruyère, Tommy Cederholm, Francesca Cerreta, Antonio Cherubini, Cyrus Cooper, Alphonso Cruz-Jentoft, Eugene MccloskeyBess Dawson-Hughes, Jean-Marc Kaufman, Andrea Laslop, Jean Petermans, Jean-Yves Reginster, René Rizzoli, Sian Robinson, Yves Rolland, Ricardo Rueda, Bruno Vellas, John A. Kanis

Risultato della ricerca: Contributo in rivistaArticolo in rivista

206 Citazioni (Scopus)


Background: All proposed definitions of sarcopenia include the measurement of muscle mass, but the techniques and threshold values used vary. Indeed, the literature does not establish consensus on the best technique for measuring lean body mass. Thus, the objective measurement of sarcopenia is hampered by limitations intrinsic to assessment tools. The aim of this study was to review the methods to assess muscle mass and to reach consensus on the development of a reference standard. Methods: Literature reviews were performed by members of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis working group on frailty and sarcopenia. Face-to-face meetings were organized for the whole group to make amendments and discuss further recommendations. Results: A wide range of techniques can be used to assess muscle mass. Cost, availability, and ease of use can determine whether the techniques are better suited to clinical practice or are more useful for research. No one technique subserves all requirements but dual energy X-ray absorptiometry could be considered as a reference standard (but not a gold standard) for measuring muscle lean body mass. Conclusions: Based on the feasibility, accuracy, safety, and low cost, dual energy X-ray absorptiometry can be considered as the reference standard for measuring muscle mass.
Lingua originaleEnglish
pagine (da-a)269-278
Numero di pagine10
RivistaJournal of Cachexia, Sarcopenia and Muscle
Stato di pubblicazionePubblicato - 2018


  • Applied Microbiology and Biotechnology
  • Biophysics
  • Lean body mass
  • Lean mass
  • Muscle mass
  • Orthopedics and Sports Medicine
  • Physiology (medical)
  • Reference standard


Entra nei temi di ricerca di 'Pitfalls in the measurement of muscle mass: a need for a reference standard'. Insieme formano una fingerprint unica.

Cita questo