Pilot study for congenital hypothyroidism, preliminary report

Costantino Romagnoli, Giuseppe Segni, M Carta Sorcini, L Fiore, S Tomarchio, S Carta, V Currò

Risultato della ricerca: Contributo in rivistaArticolo in rivista

4 Citazioni (Scopus)


Preliminary results of a pilot study on congenital hypothyroidism performed on 8,025 newborns in Italy over a 10-month period are reported. The determination of both T4 and TSH on dried blood, spotted on filter paper, as screening procedure at day 3-5 of life revealed three cases of primary hypothyroidism and one case of hypo-thyroxin-binding-globulinemia (hypo-TBG-emia). The diagnosis of primary hypothyroidism was established on the basis of low T4 and high TSH levels in two of the three cases; in the third, with elevated TSH and normal T4 levels at screening, thyroid scintiscan showed an ectopic gland located at the base of the tongue. In the case of hypo-TBG-emia, low T4 and TBG levels were associated with normal TSH values. Some cases of transient hypothyroidism were observed in premature infants.
Lingua originaleEnglish
pagine (da-a)181-184
Numero di pagine4
RivistaJournal of Endocrinological Investigation
Stato di pubblicazionePubblicato - 1980
Pubblicato esternamente


  • Congenital Hypothyroidism
  • Female
  • Humans
  • Hypothyroidism
  • Infant, Newborn
  • Infant, Newborn, Diseases
  • Intellectual Disability
  • Male
  • Mass Screening
  • Pilot Projects
  • Thyrotropin
  • Thyroxine


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