Phytocomplex influences antimicrobial and health properties of concentrated glycerine macerates

Maura Di Vito, Margherita Gentile, Paola Mattarelli, Lorenzo Barbanti, Laura Micheli, Claudia Mazzuca, Stefania Garzoli, Mattia Titubante, Alberto Vitali, Margherita Cacaci, Maurizio Sanguinetti, Francesca Bugli

Risultato della ricerca: Contributo in rivistaArticolo in rivista


The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway diseases. C-GMs of Carpinus betulus (CB), Ficus carica (FC), Alnus glutinosa (AG) and Ribes nigrum (RN) were studied. The quality was evaluated using HPLC and IM-SPME/GC-MS systems; anti-oxidant and anti-microbial activities were assessed by the respective DPPH test, and micro-broth dilution test performed against 10 strains of Streptococcus pyogenes and 10 probiotic strains. ELISA and MTT tests were used to assess the immunomodulatory activity and the cytotoxicity of C-GMs, respectively. A significant correlation was found between the number of active compounds and the in vitro C-GMs effectiveness. Furthermore, the C-GMs of AG showed the best anti-microbial activity on pathological strains and, together with CB, the best anti-oxidant activity. The ELISA test exhibited a good immunomodulatory activity of RN. In vitro data support the integrated use of C-GMs of CB, AG, and RN in presence of airway diseases, and highlight the importance of standard procedures in cultivation, harvest and post-harvest treatments, as a premise for C-GMs with consistent characteristics.
Lingua originaleEnglish
pagine (da-a)1-15
Numero di pagine15
Stato di pubblicazionePubblicato - 2020


  • Alnus glutinosa
  • Carpinus betulus
  • Ficus carica
  • IM-SPME/GC-MS system
  • Ribes nigrum


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