Phytocomplex influences antimicrobial and health properties of concentrated glycerine macerates

Maura Di Vito*, M. Gentile, P. Mattarelli, L. Barbanti, L. Micheli, C. Mazzuca, S. Garzoli, M. Titubante, A. Vitali, Margherita Cacaci, Maurizio Sanguinetti, Francesca Bugli

*Autore corrispondente per questo lavoro

Risultato della ricerca: Contributo in rivistaArticolo

Abstract

The purpose of this study was to correlate the chemical composition of four commercial concentrated glycerine macerates (C-GMs), produced through the same extraction method, with their in vitro antimicrobial, antioxidant, and immunomodulatory properties, in order to evaluate their potential for healing upper airway diseases. C-GMs of Carpinus betulus (CB), Ficus carica (FC), Alnus glutinosa (AG) and Ribes nigrum (RN) were studied. The quality was evaluated using HPLC and IM-SPME/GC-MS systems; anti-oxidant and anti-microbial activities were assessed by the respective DPPH test, and micro-broth dilution test performed against 10 strains of Streptococcus pyogenes and 10 probiotic strains. ELISA and MTT tests were used to assess the immunomodulatory activity and the cytotoxicity of C-GMs, respectively. A significant correlation was found between the number of active compounds and the in vitro C-GMs effectiveness. Furthermore, the C-GMs of AG showed the best anti-microbial activity on pathological strains and, together with CB, the best anti-oxidant activity. The ELISA test exhibited a good immunomodulatory activity of RN. In vitro data support the integrated use of C-GMs of CB, AG, and RN in presence of airway diseases, and highlight the importance of standard procedures in cultivation, harvest and post-harvest treatments, as a premise for C-GMs with consistent characteristics.
Lingua originaleInglese
pagine (da-a)1-15
Numero di pagine15
RivistaAntibiotics
Volume9
Numero di pubblicazione12
DOI
Stato di pubblicazionePubblicato - 2020

All Science Journal Classification (ASJC) codes

  • Microbiologia
  • Biochimica
  • Farmacologia, Tossicologia e Farmaceutica Generali
  • Microbiologia (medica)
  • Malattie Infettive
  • Farmacologia (medica)

Keywords

  • Alnus glutinosa
  • Carpinus betulus
  • Ficus carica
  • IM-SPME/GC-MS system
  • Ribes nigrum

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