TY - JOUR
T1 - Physiology and pathophysiology of liver lipid metabolism
AU - Ponziani, Francesca Romana
AU - Pecere, Silvia
AU - Gasbarrini, Antonio
AU - Ojetti, Veronica
PY - 2015
Y1 - 2015
N2 - Liver lipid metabolism and its modulation are involved in many pathologic conditions, such as obesity, non-alcoholic fatty liver disease, diabetes mellitus, atherosclerosis and cardiovascular disease. Metabolic disorders seem to share a similar background of low-grade chronic inflammation, even if the pathophysiological mechanisms leading to tissue and organ damage have not been completely clarified yet. The accumulation of neutral lipids in the liver is now recognized as a beneficial and protective mechanism; on the other hand, lipoperoxidation is involved in the development and progression of non-alcoholic steatohepatitis. The role of the gut microbiota in liver lipid metabolism has been the object of recent scientific investigations. It is likely that the gut microbiota is involved in a complex metabolic modulation and the translocation of gut microflora may also contribute to maintaining the low-grade inflammatory status of metabolic syndrome. Therefore, lipid metabolism pathology has vague limits and complex mechanisms, and the knowledge of these is essential to guide diagnostic and therapeutic decisions.
AB - Liver lipid metabolism and its modulation are involved in many pathologic conditions, such as obesity, non-alcoholic fatty liver disease, diabetes mellitus, atherosclerosis and cardiovascular disease. Metabolic disorders seem to share a similar background of low-grade chronic inflammation, even if the pathophysiological mechanisms leading to tissue and organ damage have not been completely clarified yet. The accumulation of neutral lipids in the liver is now recognized as a beneficial and protective mechanism; on the other hand, lipoperoxidation is involved in the development and progression of non-alcoholic steatohepatitis. The role of the gut microbiota in liver lipid metabolism has been the object of recent scientific investigations. It is likely that the gut microbiota is involved in a complex metabolic modulation and the translocation of gut microflora may also contribute to maintaining the low-grade inflammatory status of metabolic syndrome. Therefore, lipid metabolism pathology has vague limits and complex mechanisms, and the knowledge of these is essential to guide diagnostic and therapeutic decisions.
KW - NAFLD
KW - NASH
KW - cardiovascular disease
KW - cholesterol
KW - gut microbiota
KW - liver lipid metabolism
KW - metabolic syndrome
KW - NAFLD
KW - NASH
KW - cardiovascular disease
KW - cholesterol
KW - gut microbiota
KW - liver lipid metabolism
KW - metabolic syndrome
UR - https://publicatt.unicatt.it/handle/10807/68225
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84937548134&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84937548134&origin=inward
U2 - 10.1586/17474124.2015.1056156
DO - 10.1586/17474124.2015.1056156
M3 - Article
SN - 1747-4124
VL - 9
SP - 1055
EP - 1067
JO - Expert Review of Gastroenterology and Hepatology
JF - Expert Review of Gastroenterology and Hepatology
IS - 8
ER -