TY - JOUR
T1 - Phenylephrine eye drops in pediatric patients undergoing ophthalmic surgery: Incidence, presentation, and management of complications during general anesthesia
AU - Sbaraglia, Fabio
AU - Mores, Nadia
AU - Garra, Rossella
AU - Giuratrabocchetta, Giuseppe
AU - Lepore, Domenico
AU - Molle, Fernando
AU - Savino, Gustavo
AU - Piastra, Marco
AU - Pulitano', Silvia Maria
AU - Sammartino, Maria
PY - 2014
Y1 - 2014
N2 - Background: Phenylephrine eye drops are widely used as mydriatic agent to reach the posterior segment of the eye. In literature, many reports suggest a systemic absorption of this agent as a source of severe adverse drug reactions. Hence, we reviewed our experience with topical phenylephrine in ophthalmic surgery. Methods: In May 2006, following US guidelines publication, a standard operating procedure was issued in our operating rooms to standardize the use of phenylephrine eye drops in our practice. Two years later, after the occurrence of a cluster of serious adverse drug reactions in infants undergoing surgery, a review of phenylephrine safety and systemic complications incidence was performed. Results: We observed 451 pediatric patients, and 187 met the inclusions criteria: Among them, 4 experienced hemodynamic complications due to phenylephrine eye drops. The incidence of major complications was 2.1%. Conclusions: Two different patterns of side effects occurred. The first one was a cardiovascular derangement with severe hypertension and heart rate alterations; the other one involved exclusively pulmonary circuit causing early edema. These clinical manifestations, their duration, and treatment responses are all explainable by alfa1-adrenergic action of phenylephrine. This hypothetic pathogenesis has been confirmed also by the usefulness of direct vasodilators (anesthetic agents) and by the negative outcome occurred in the past with the use of beta-blockers
AB - Background: Phenylephrine eye drops are widely used as mydriatic agent to reach the posterior segment of the eye. In literature, many reports suggest a systemic absorption of this agent as a source of severe adverse drug reactions. Hence, we reviewed our experience with topical phenylephrine in ophthalmic surgery. Methods: In May 2006, following US guidelines publication, a standard operating procedure was issued in our operating rooms to standardize the use of phenylephrine eye drops in our practice. Two years later, after the occurrence of a cluster of serious adverse drug reactions in infants undergoing surgery, a review of phenylephrine safety and systemic complications incidence was performed. Results: We observed 451 pediatric patients, and 187 met the inclusions criteria: Among them, 4 experienced hemodynamic complications due to phenylephrine eye drops. The incidence of major complications was 2.1%. Conclusions: Two different patterns of side effects occurred. The first one was a cardiovascular derangement with severe hypertension and heart rate alterations; the other one involved exclusively pulmonary circuit causing early edema. These clinical manifestations, their duration, and treatment responses are all explainable by alfa1-adrenergic action of phenylephrine. This hypothetic pathogenesis has been confirmed also by the usefulness of direct vasodilators (anesthetic agents) and by the negative outcome occurred in the past with the use of beta-blockers
KW - Adverse drug reaction
KW - Pediatric anesthesia
KW - Phenylephrine
KW - Adverse drug reaction
KW - Pediatric anesthesia
KW - Phenylephrine
UR - http://hdl.handle.net/10807/50515
U2 - 10.1111/pan.12329
DO - 10.1111/pan.12329
M3 - Article
SN - 1155-5645
VL - 24
SP - 400
EP - 405
JO - Paediatric Anaesthesia
JF - Paediatric Anaesthesia
ER -