Phenotypic Variability in Acquired and Idiopathic Dystonia

Giovanni Defazio, Angelo Fabio Gigante, Roberto Erro, Daniele Belvisi, Marcello Esposito, Assunta Trinchillo, Gabriella De Joanna, Roberto Ceravolo, Sonia Mazzucchi, Elisa Unti, Paolo Barone, Sara Scannapieco, Maria Sofia Cotelli, Marinella Turla, Marta Bianchi, Laura Bertolasi, Antonio Pisani, Francesca Valentino, Maria Concetta Altavista, Vincenzo MoschellaPaolo Girlanda, Carmen Terranova, Francesco Bono, Giorgio Spano, Giovanni Fabbrini, Gina Ferrazzano, Alberto Albanese, Anna Castagna, Daniela Cassano, Mario Coletti Moja, Roberta Pellicciari, Anna Rita Bentivoglio, Roberto Eleopra, Giovanni Cossu, Tommaso Ercoli, Marcello Mario Mascia, Francesca Di Biasio, Salvatore Misceo, Luca Magistrelli, Marcello Romano, Cesa Lorella Maria Scaglione, Michele Tinazzi, Luca Maderna, Maurizio Zibetti, Alfredo Berardelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

BackgroundTo date, a few studies have systematically investigated differences in the clinical spectrum between acquired and idiopathic dystonias. ObjectivesTo compare demographic data and clinical features in patients with adult-onset acquired and idiopathic dystonias. MethodsPatients were identified from among those included in the Italian Dystonia Registry, a multicenter Italian dataset of patients with adult-onset dystonia. Study population included 116 patients with adult-onset acquired dystonia and 651 patients with isolated adult-onset idiopathic dystonia. ResultsComparison of acquired and idiopathic dystonia revealed differences in the body distribution of dystonia, with oromandibular dystonia, limb and trunk dystonia being more frequent in patients with acquired dystonia. The acquired dystonia group was also characterized by lower age at dystonia onset, greater tendency to spread, lower frequency of head tremor, sensory trick and eye symptoms, and similar frequency of neck pain associated with CD and family history of dystonia/tremor. ConclusionsThe clinical phenomenology of dystonia may differ between acquired and idiopathic dystonia, particularly with regard to the body localization of dystonia and the tendency to spread. This dissimilarity raises the possibility of pathophysiological differences between etiologic categories.
Lingua originaleEnglish
pagine (da-a)1107-1113
Numero di pagine7
RivistaMovement Disorders Clinical Practice
Volume10
DOI
Stato di pubblicazionePubblicato - 2023

Keywords

  • acquired
  • idiopathic
  • dystonia
  • clinical phenomenology

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