Phenobarbital for treatment of seizures in preterm infant: a new administration scheme

Maria Pia De Carolis, Costantino Romagnoli, Antonio Alberto Zuppa, Enrico Zecca, Giuseppe Gio Batta Tortorolo, U Muzii

Risultato della ricerca: Contributo in rivistaArticolo in rivista

7 Citazioni (Scopus)

Abstract

The serum concentration of phenobarbital used as an anticonvulsant was monitored in 30 preterm babies. The therapeutic serum concentration was achieved with a loading dose of 20 mg/kg i.v., 10 min after administration. Thirty-six hours after loading, it was possible to maintain therapeutic serum levels with a daily intramuscular dose of 5 mg/kg, avoiding toxicity. A comparison of CSF and serum concentrations indicated that the drug passage to CSF is rapid and depends on a brain lesion. Serum monitoring of phenobarbital is important in preterm neonates under 30 weeks gestation and/or with severe pathological complications.
Lingua originaleEnglish
pagine (da-a)84-89
Numero di pagine6
RivistaDevelopmental Pharmacology and Therapeutics
Volume14
Stato di pubblicazionePubblicato - 1989

Keywords

  • Drug Administration Schedule
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Phenobarbital
  • Seizures

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