Pharmacotherapy of acute alcoholic hepatitis in clinical practice

Giovanni Addolorato, Ludovico Abenavoli, Natasa Milic, Samir Rouabhia

Risultato della ricerca: Contributo in rivistaArticolo in rivista

12 Citazioni (Scopus)

Abstract

Severe alcoholic hepatitis (AH) is an acute form of alcohol induced liver disease with a poor prognosis that is seen in the patients who consume large quantities of alcohol. The diagnosis of AH is based on the appropriate alcohol intake history and is supported with clinical and histological features, and several scoring systems. Glucocorticoids are the mainstay for treating severe AH with pentoxifylline used as an alternative to steroids in addition to total alcohol abstinence. Liver transplantation is a possible therapeutic option for severe AH. Among the anti-craving medications able to improve abstinence rate, baclofen seems to be effective and safe in the alcoholic patients affected by severe liver damage.
Lingua originaleEnglish
pagine (da-a)2159-2167
Numero di pagine9
RivistaWORLD JOURNAL OF GASTROENTEROLOGY
Volume20
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • Alcoholic liver disease
  • Baclofen
  • Severe alcoholic hepatitis

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