TY - JOUR
T1 - Pharmacological treatment of chronic obstructive pulmonary disease: from evidence-based medicine to phenotyping
AU - Montuschi, Paolo
AU - Malerba, Mario
AU - Santini, Giuseppe
AU - Miravitlles, Marc
PY - 2014
Y1 - 2014
N2 - Chronic obstructive pulmonary disease (COPD) is characterized by large phenotype variability, reflected by a highly variable response to pharmacological treatment. Nevertheless, current guidelines suggest that patients with COPD of similar severity should be treated in the same way. The phenotype-based pharmacotherapeutic approach proposes bronchodilators alone in the nonfrequent exacerbator phenotype and a combination of bronchodilators and inhaled corticosteroids in patients with asthma-COPD overlap syndrome (ACOS) and moderate-to-severe exacerbator phenotype. The clinical importance of phenotypes is changing the paradigm of COPD management from evidence-based to personalized medicine. However, the personalized pharmacological strategy of COPD has to be validated in future clinical studies
AB - Chronic obstructive pulmonary disease (COPD) is characterized by large phenotype variability, reflected by a highly variable response to pharmacological treatment. Nevertheless, current guidelines suggest that patients with COPD of similar severity should be treated in the same way. The phenotype-based pharmacotherapeutic approach proposes bronchodilators alone in the nonfrequent exacerbator phenotype and a combination of bronchodilators and inhaled corticosteroids in patients with asthma-COPD overlap syndrome (ACOS) and moderate-to-severe exacerbator phenotype. The clinical importance of phenotypes is changing the paradigm of COPD management from evidence-based to personalized medicine. However, the personalized pharmacological strategy of COPD has to be validated in future clinical studies
KW - Asthma-COPD overlap syndrome
KW - Chronic obstructive pulmonary disease (COPD)
KW - Evidence-based medicine
KW - Inhaled corticosteroids
KW - Personalised pharmacological treatment
KW - Pharmacotherapy
KW - Phenotyping
KW - Asthma-COPD overlap syndrome
KW - Chronic obstructive pulmonary disease (COPD)
KW - Evidence-based medicine
KW - Inhaled corticosteroids
KW - Personalised pharmacological treatment
KW - Pharmacotherapy
KW - Phenotyping
UR - http://hdl.handle.net/10807/60977
U2 - 10.1016/j.drudis.2014.08.004
DO - 10.1016/j.drudis.2014.08.004
M3 - Article
SN - 1359-6446
VL - 19
SP - 1928
EP - 1935
JO - Drug Discovery Today
JF - Drug Discovery Today
ER -