Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis

Roberta Gagliardini; Massimiliano Fabbiani; Serena Fortuna; Elena Visconti; Pierluigi Navarra; Roberto Cauda; Manuela Colafigli; A. De Luca; Andrea De Luca; Enrico Maria Trecarichi; Simona Di Giambenedetto

doi:10.1007/s15010-014-0599-z

Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis

Roberta Gagliardini, Massimiliano Fabbiani, Serena Fortuna, Elena Visconti, Pierluigi Navarra, Roberto Cauda, Manuela Colafigli, A. De Luca, Andrea De Luca, Enrico Maria Trecarichi, Simona Di Giambenedetto

Azienda Ospedaliera Universitaria Senese

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

6 Citazioni (Scopus)

Abstract

Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.

Lingua originale	English
pagine (da-a)	N/A-N/A
Rivista	Infection
Volume	2014
DOI	https://doi.org/10.1007/s15010-014-0599-z
Stato di pubblicazione	Pubblicato - 2014

Keywords

HIV
etravirine
pharmacokinetics
tubercolosis

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title = "Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis",

abstract = "Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.",

keywords = "HIV, etravirine, pharmacokinetics, tubercolosis, HIV, etravirine, pharmacokinetics, tubercolosis",

author = "Roberta Gagliardini and Massimiliano Fabbiani and Serena Fortuna and Elena Visconti and Pierluigi Navarra and Roberto Cauda and Manuela Colafigli and {De Luca}, A. and {De Luca}, Andrea and Trecarichi, {Enrico Maria} and {Di Giambenedetto}, Simona",

year = "2014",

doi = "10.1007/s15010-014-0599-z",

language = "English",

volume = "2014",

pages = "N/A--N/A",

journal = "Infection",

issn = "0300-8126",

publisher = "Urban und Vogel",

}

TY - JOUR

T1 - Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis

AU - Gagliardini, Roberta

AU - Fabbiani, Massimiliano

AU - Fortuna, Serena

AU - Visconti, Elena

AU - Navarra, Pierluigi

AU - Cauda, Roberto

AU - Colafigli, Manuela

AU - De Luca, A.

AU - De Luca, Andrea

AU - Trecarichi, Enrico Maria

AU - Di Giambenedetto, Simona

PY - 2014

Y1 - 2014

N2 - Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.

AB - Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.

KW - HIV

KW - etravirine

KW - pharmacokinetics

KW - tubercolosis

KW - HIV

KW - etravirine

KW - pharmacokinetics

KW - tubercolosis

UR - http://hdl.handle.net/10807/54201

U2 - 10.1007/s15010-014-0599-z

DO - 10.1007/s15010-014-0599-z

M3 - Article

SN - 0300-8126

VL - 2014

SP - N/A-N/A

JO - Infection

JF - Infection

ER -

Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis

Abstract

Keywords

OSS delle Nazioni Unite

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