Pharmacokinetics of etravirine in HIV-infected patients concomitantly treated with rifampin for tuberculosis

Pierluigi Navarra, Roberto Cauda, Simona Di Giambenedetto, Roberta Gagliardini, Massimiliano Fabbiani, Serena Fortuna, Elena Visconti, Manuela Colafigli, Andrea De Luca, Enrico Maria Trecarichi, A. De Luca

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

6 Citazioni (Scopus)

Abstract

Etravirine is metabolized by three cytochrome P450 enzymes that are in turn induced by rifampin. Consequently, co-administration of etravirine and rifampin is not recommended. To date, however, no clinical studies exploring the drug-drug interaction of this combination have been conducted. Here we report two cases of off-label etravirine use concurrently with antitubercular treatment, dictated by the unavailability of other treatments. Plasma drug concentrations were monitored by regular measurements. Our results appear to confirm the increased metabolism of etravirine through the induction of cytochrome P450 enzymes, but the adequacy of drug levels in all of the measurements and subsequent virological suppression suggest that this drug interaction may not be clinically relevant.
Lingua originaleEnglish
pagine (da-a)N/A-N/A
RivistaInfection
Volume2014
DOI
Stato di pubblicazionePubblicato - 2014

Keywords

  • HIV
  • etravirine
  • pharmacokinetics
  • tubercolosis

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