Pharmacokinetic variability of antiretroviral drugs and correlation with virological outcome: two years experience in routine clinical practice

Simona Di Giambenedetto, Roberto Cauda, Pierluigi Navarra, Massimiliano Fabbiani, Laura Bracciale, Alessandra Bacarelli, Enzo Ragazzoni, Andrea De Luca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

OBJECTIVES: To assess the inter-individual and intra-individual plasma concentration variabilities of non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs) in routine clinical practice and to investigate their relationships with virological failure. METHODS: We retrospectively enrolled HIV-infected patients undergoing therapeutic drug monitoring (TDM) of NNRTIs and PIs during routine outpatient visits. Plasma drug concentrations were measured by HPLC-UV and were considered therapeutic if above the proposed minimum efficacy trough concentration. Inter-individual and intra-individual variabilities were evaluated through the coefficient of variation (CV). RESULTS: A total of 457 PI and 172 NNRTI plasma concentrations were measured from 363 patients (HIV-RNA <50 copies/mL in 70.8%, median CD4 count 434 cells/mm(3)). NNRTIs showed less inter-individual (CV(inter) 54.8% versus 84.3%) and intra-individual (CV(intra) 19.0% versus 38.1%) pharmacokinetic variabilities
Lingua originaleEnglish
pagine (da-a)109-117
Numero di pagine9
RivistaJournal of Antimicrobial Chemotherapy
Stato di pubblicazionePubblicato - 2009

Keywords

  • TDM
  • antiretrovirali

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