Pharmacokinetic analysis of azelaic acid disodium salt. A proposed substrate for total parenteral nutrition

Geltrude Mingrone, A Bertuzzi, A Gandolfi, S Salinari, E Arcieri Mastromattei, E Finotti, Av Greco

Risultato della ricerca: Contributo in rivistaArticolo in rivista

27 Citazioni (Scopus)

Abstract

Azelaic acid was the first dicarboxylic acid proposed as an alternative energy substrate in total parenteral nutrition. In this study, the pharmacokinetics of azelaic acid were investigated in 12 healthy volunteers, 7 receiving a constant infusion (10g over 90 min) and 5 a bolus dose (1g). The 24h urinary excretion and plasma concentration in blood samples taken at regular intervals were assayed by gas-liquid chromatography. Experimental data were analysed by a 2-compartment nonlinear model that describes both tubular secretion and cellular uptake in Michaelis-Menten terms. A high value of urinary excretion (mean 76.9% of infused dose) and a mean clearance of 8.42 L/h were found, suggesting the presence of tubular secretion. Estimating the population mean of the pharmacokinetic model parameters gave a maximal cellular uptake of 0.657 g/h. The model predicts that 90% of the maximal uptake should be reached in the plateau phase of a constant infusion of 2.2 g/h. The presence of extensive and rapid losses through urinary excretion, and the low estimated value of the maximal cellular uptake, indicate that azelaic acid is not suitable as an energy substrate for total parenteral nutrition.
Lingua originaleEnglish
pagine (da-a)411-419
Numero di pagine9
RivistaClinical Pharmacokinetics
Volume20
Stato di pubblicazionePubblicato - 1991

Keywords

  • Adult
  • Chromatography, Gas
  • Dicarboxylic Acids
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Models, Biological
  • Parenteral Nutrition, Total

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