PGRS domain structures: Doomed to sail the mycomembrane

Rita Berisio; Giovanni Delogu

doi:10.1371/journal.ppat.1010760

PGRS domain structures: Doomed to sail the mycomembrane

Rita Berisio, Giovanni Delogu

National Research Council of Italy

Risultato della ricerca: Contributo in rivista › Articolo

Abstract

The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.

Lingua originale	Inglese
pagine (da-a)	e1010760-N/A
Rivista	PLoS Pathogens
Volume	18
DOI	https://doi.org/10.1371/journal.ppat.1010760
Stato di pubblicazione	Pubblicato - 2022

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AB - The impact of artificial intelligence (AI) in understanding biological processes is potentially immense. Structural elucidation of mycobacterial PE_PGRS is sustenance to unveil the role of these enigmatic proteins. We propose a PGRS "sailing" model as a smart tool to diffuse along the mycomembrane, to expose structural motifs for host interactions, and/or to ship functional protein modules at their C-terminus.

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PGRS domain structures: Doomed to sail the mycomembrane

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