PET in inflammatory bowel diseases: a new FAPI era?

Purpose: To evaluate the role of experimental FAPI PET/CT in inflammatory bowel diseases. Methods: First clinical papers about FAPI PET/CT in inflammatory bowel diseases were retrieved in scientific literature and commented in this short review, compared with conventional clinical and radiological examinations (e.g. CT, MRI and 18F-FDG PET/CT). Results: Only few first-in-human trials have been published until now about the role of experimental FAPI PET/CT in inflammatory bowel diseases, showing interesting accuracy data and possible impact on clinical management in patients with Crohn’s disease. Conclusion: Larger studies are needed to confirm and expand the role of this diagnostic tool in clinics.