TY - JOUR
T1 - Personalized bone reconstruction and regeneration in the treatment of craniosynostosis
AU - Tiberio, Federica
AU - Cacciotti, Ilaria
AU - Frassanito, Paolo
AU - Nocca, Giuseppina
AU - Tamburrini, Gianpiero
AU - Arcovito, Alessandro
AU - Lattanzi, Wanda
PY - 2021
Y1 - 2021
N2 - Craniosynostosis (CS) is the second most prevalent craniofacial congenital malformation due to the premature fusion of skull sutures. CS care requires surgical treatment of variable complexity, aimed at resolving functional and cosmetic defects resulting from the skull growth constrain. Despite significant innovation in the management of CS, morbidity and mortality still exist. Residual cranial defects represent a potential complication and needdedicated management to drive a targeted bone regeneration while modulating suture ossification. To this aim, existing techniques are rapidly evolving and include the implementation of novel biomaterials, 3D printing and additive manufacturing techniques, and advanced therapies based on tissue engineering. This review aims at providing an exhaustive and up‐to‐date overview of the strategies in use to correct these congenital defects, focusing on the technological advances in the fields of biomaterials and tissue engineering implemented in pediatric surgical skull reconstruction, i.e., biodegradable bone fixation systems, biomimetic scaffolds, drug delivery systems, and cell‐based approaches.
AB - Craniosynostosis (CS) is the second most prevalent craniofacial congenital malformation due to the premature fusion of skull sutures. CS care requires surgical treatment of variable complexity, aimed at resolving functional and cosmetic defects resulting from the skull growth constrain. Despite significant innovation in the management of CS, morbidity and mortality still exist. Residual cranial defects represent a potential complication and needdedicated management to drive a targeted bone regeneration while modulating suture ossification. To this aim, existing techniques are rapidly evolving and include the implementation of novel biomaterials, 3D printing and additive manufacturing techniques, and advanced therapies based on tissue engineering. This review aims at providing an exhaustive and up‐to‐date overview of the strategies in use to correct these congenital defects, focusing on the technological advances in the fields of biomaterials and tissue engineering implemented in pediatric surgical skull reconstruction, i.e., biodegradable bone fixation systems, biomimetic scaffolds, drug delivery systems, and cell‐based approaches.
KW - Additive manufacturing
KW - Biomaterials
KW - Calvarial bone reconstruction
KW - Craniosynostosis
KW - Delivery systems
KW - Innovative biotechnologies
KW - Mesenchymal stromal cells
KW - Personalized medicine
KW - Tissue engineering
KW - Additive manufacturing
KW - Biomaterials
KW - Calvarial bone reconstruction
KW - Craniosynostosis
KW - Delivery systems
KW - Innovative biotechnologies
KW - Mesenchymal stromal cells
KW - Personalized medicine
KW - Tissue engineering
UR - http://hdl.handle.net/10807/177111
U2 - 10.3390/app11062649
DO - 10.3390/app11062649
M3 - Article
SN - 2076-3417
VL - 11
SP - 2649-N/A
JO - APPLIED SCIENCES
JF - APPLIED SCIENCES
ER -