Personality traits and cortical activity affect gambling behavior in Parkinson's disease

Michela Balconi, Laura Angioletti, Chiara Siri, Nicoletta Meucci, Gianni Pezzoli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

6 Citazioni (Scopus)

Abstract

Background: Pathological gambling (PG) in Parkinson's disease (PD) manifests as a persistent and uncontrollable gambling behavior, characterized by dysfunctional decision-making and emotional impairment related to high-risk decisions. Objective: The aim of this study was to explore the relationship between personality traits and prefrontal cortex activity in PD patients with or without PG. Methods: Thus, hemodynamic cortical activity measured by functional near-infrared spectroscopy (fNIRS) and Iowa Gambling Task (IGT) performance were recorded in forty-six PD patients, divided into three groups according to their gambling status: PD patients with active gambling behavior (PDG); PD patients who remitted from PG (PDNG); and a control group (CG) composed by patients with PD only. Results: Results indicates that gambling behavior in PD patients is strongly predictive of dysfunctional cognitive strategy; affecting anomalous cortical response with a left hemispheric unbalance in dorsal areas; and it is related to more reward sensitivity than impulsivity personality components. Conclusions: PDG patients differed from PDNG and CG from both behavioral and brain response to decision-making. Overall, these effects confirm a pathological condition related to cognitive and emotional aspects which makes the patients with PGD victims of their dysfunctional behavior.
Lingua originaleEnglish
pagine (da-a)341-352
Numero di pagine12
RivistaJournal of Parkinson's Disease
Volume8
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • Gambling behavior
  • IGT
  • Parkinson's disease
  • fNIRS
  • impulsivity
  • reward sensitivity

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