Peripapillary Retinal Vascular Involvement in Early Post-COVID-19 Patients

Alfonso Savastano, Emanuele Crincoli, Maria Cristina Savastano, Gloria Gambini, Carola Culiersi, Stanislao Rizzo

Risultato della ricerca: Contributo in rivistaArticolo in rivista


The ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ' s) to cause multi-organ ischemia and coronavirus-induced posterior segment eye diseases in mammals gave concern about potential sight-threatening ischemia in post coronavirus disease 2019 patients. The radial peripapillary capillary plexus (RPCP) is a sensitive target due to the important role in the vascular supply of the peripapillary retinal nerve fiber layer (RNFL). Eighty patients one month after SARS-CoV-2 infection and 30 healthy patients were selected to undergo structural OCT (optical coherence tomography) and OCTA (optical coherence tomography angiography) exams. Primary outcome was a difference in RPCP perfusion density (RPCP-PD) and RPCP flow index (RPCP-FI). No significant difference was observed in age, sex, intraocular pressure (IOP) and prevalence of myopia. RPCP-PD was lower in post SARS-CoV-2 patients compared to controls. Within the post-COVID-19 group, patients with systemic arterial hypertension had lower RPCP-FI and age was inversely correlated to both RPCP-FI and RPCP-PD. Patients treated with lopinavir + ritonavir or antiplatelet therapy during admission had lower RPCP-FI and RPCP-PD. RNFL average thickness was linearly correlated to RPCP-FI and RPCP-PD within post-COVID-19 group. Future studies will be needed to address the hypothesis of a microvascular retinal impairment in individuals who recovered from SARS-CoV-2 infection.
Lingua originaleEnglish
pagine (da-a)2895-2895
Numero di pagine1
RivistaJournal of Clinical Medicine
Stato di pubblicazionePubblicato - 2020


  • OCT angiography
  • SARS-CoV-2
  • peripapillary capillary perfusion
  • personalized medicine


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