Perioperative HDR brachytherapy for reirradiation in head and neck recurrences: Single-institution experience and systematic review

Maria Antonietta Gambacorta, Gian Carlo Mattiucci, Mario Balducci, Jacopo Galli, Gaetano Paludetti, Vincenzo Valentini, Luca Tagliaferri, Francesco Bussu, Bruno Fionda, Francesco Catucci, Mario Rigante, Rosa Autorino, Francesco Micciche', Elisa Placidi, György Kovacs

Risultato della ricerca: Contributo in rivistaArticolo in rivista

15 Citazioni (Scopus)

Abstract

Aim: The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature. Materials and methods: Patients treated with prior radiation doses > 65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library. Results: Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review. Conclusions: IMBT could play an important role in the retreatment of recurrent head and neck cancer.
Lingua originaleEnglish
pagine (da-a)516-524
Numero di pagine9
RivistaTumori
Volume103
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Brachytherapy
  • Cancer Research
  • Female
  • HDR
  • Head and Neck Neoplasms
  • Head and neck cancer
  • Humans
  • Male
  • Neoplasm Recurrence, Local
  • Oncology
  • Radiotherapy
  • Radiotherapy, Intensity-Modulated
  • Re-Irradiation
  • Recurrence

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