Percutaneous laser ablation of hepatocellular carcinoma in patients with liver cirrhosis awaiting liver transplantation

Maurizio Pompili, Gian Ludovico Rapaccini, Giovanni Battista Gasbarrini, Erica Nicolardi, Claudio Maurizio Pacella, Giampiero Francica, Mario Angelico, Giuseppe Tisone, Paolo Craboledda

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

Objective: The aim of this study was to determine the effectiveness and safety of percutaneous laser ablation for the treatment of cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation. Materials and methods: The data of 9 male cirrhotic patients (mean age 50 years, range 45 60 years) with 12 biopsy proven nodules of hepatocellular carcinoma (mean diameter 2.0 cm, range 1.0 3.0 cm) treated by laser ablation before liver transplantation between June 2000 and January 2006 were retrospectively reviewed. Laser ablation was carried out by inserting 300 nm optical fibers through 21-Gauge needles (from two to four) positioned under ultrasound guidance into the target lesions. A continuous wave Neodymium:Yttrium Aluminium Garnet laser was used. Transarterial chemoembolization prior to liver transplantation was performed in two incompletely ablated tumors. Results: No procedure-related major complicationswere recorded. During thewaiting time to liver transplantation local tumor progression after ablation occurred in 3 nodules (25%). At histological examination of the explanted livers complete necrosiswas found in 8 nodules (66.7%, all treated exclusively with laser ablation), partial necrosis >50% in 3 nodules (25%), and partial necrosis <50% in 1 nodule. Conclusion: In patients with cirrhotic livers awaiting liver transplantation, percutaneous laser ablation is safe and effective for the management of small hepatocellular carcinoma.
Lingua originaleEnglish
pagine (da-a)e6-e11
Numero di pagine6
RivistaEuropean Journal of Radiology
Stato di pubblicazionePubblicato - 2009

Keywords

  • liver transplantation
  • percutaneous laser ablation
  • small hepatocellular carcinoma

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