TY - JOUR
T1 - Percutaneous laser ablation of hepatocellular carcinoma in patients with liver cirrhosis awaiting liver transplantation
AU - Pompili, Maurizio
AU - Pacella, Claudio Maurizio
AU - Francica, Giampiero
AU - Angelico, Mario
AU - Tisone, Giuseppe
AU - Craboledda, Paolo
AU - Nicolardi, Erica
AU - Rapaccini, Gian Ludovico
AU - Gasbarrini, Giovanni Battista
PY - 2009
Y1 - 2009
N2 - Objective: The aim of this study was to determine the effectiveness and safety of percutaneous laser ablation
for the treatment of cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation.
Materials and methods: The data of 9 male cirrhotic patients (mean age 50 years, range 45 60 years) with
12 biopsy proven nodules of hepatocellular carcinoma (mean diameter 2.0 cm, range 1.0 3.0 cm) treated
by laser ablation before liver transplantation between June 2000 and January 2006 were retrospectively
reviewed. Laser ablation was carried out by inserting 300 nm optical fibers through 21-Gauge needles
(from two to four) positioned under ultrasound guidance into the target lesions. A continuous wave
Neodymium:Yttrium Aluminium Garnet laser was used. Transarterial chemoembolization prior to liver
transplantation was performed in two incompletely ablated tumors.
Results: No procedure-related major complicationswere recorded. During thewaiting time to liver transplantation
local tumor progression after ablation occurred in 3 nodules (25%). At histological examination
of the explanted livers complete necrosiswas found in 8 nodules (66.7%, all treated exclusively with laser
ablation), partial necrosis >50% in 3 nodules (25%), and partial necrosis <50% in 1 nodule.
Conclusion: In patients with cirrhotic livers awaiting liver transplantation, percutaneous laser ablation is
safe and effective for the management of small hepatocellular carcinoma.
AB - Objective: The aim of this study was to determine the effectiveness and safety of percutaneous laser ablation
for the treatment of cirrhotic patients with hepatocellular carcinoma awaiting liver transplantation.
Materials and methods: The data of 9 male cirrhotic patients (mean age 50 years, range 45 60 years) with
12 biopsy proven nodules of hepatocellular carcinoma (mean diameter 2.0 cm, range 1.0 3.0 cm) treated
by laser ablation before liver transplantation between June 2000 and January 2006 were retrospectively
reviewed. Laser ablation was carried out by inserting 300 nm optical fibers through 21-Gauge needles
(from two to four) positioned under ultrasound guidance into the target lesions. A continuous wave
Neodymium:Yttrium Aluminium Garnet laser was used. Transarterial chemoembolization prior to liver
transplantation was performed in two incompletely ablated tumors.
Results: No procedure-related major complicationswere recorded. During thewaiting time to liver transplantation
local tumor progression after ablation occurred in 3 nodules (25%). At histological examination
of the explanted livers complete necrosiswas found in 8 nodules (66.7%, all treated exclusively with laser
ablation), partial necrosis >50% in 3 nodules (25%), and partial necrosis <50% in 1 nodule.
Conclusion: In patients with cirrhotic livers awaiting liver transplantation, percutaneous laser ablation is
safe and effective for the management of small hepatocellular carcinoma.
KW - liver transplantation
KW - percutaneous laser ablation
KW - small hepatocellular carcinoma
KW - liver transplantation
KW - percutaneous laser ablation
KW - small hepatocellular carcinoma
UR - http://hdl.handle.net/10807/12889
M3 - Article
SN - 0720-048X
SP - e6-e11
JO - European Journal of Radiology
JF - European Journal of Radiology
ER -