Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial

Anselmo Caricato, Roberto Colombo, Pietro Caironi, Serge Masson, Tommaso Mauri, Barbara Bottazzi, Roberto Leone, Michela Magnoli, Simona Barlera, Filippo Mamprin, Andrea Fedele, Alberto Mantovani, Gianni Tognoni, Antonio Pesenti, Luciano Gattinoni, Roberto Latini, Paola Bruzzone, Francesca Pagan, Riccarda Russo, Andrea ConfalonieriChiara Abbruzzese, Beatrice Vergnano, Stefano Faenza, Antonio Siniscalchi, Elisabetta Pierucci, Andrea Noto, Angelo Pezzi, Paolo Spanu, Vieri Parrini, Roberto Oggioni, Giovanni Stefano Pasetti, Maria Cinzia Casadio, Rosa Buontempo, Sara Carrer, Francesca Piccoli, Tatiana Rizzi, Monica La Sala, Alessandra Antonaci, Paola Fassini, Silvia Paganini, Virginia Porta, Gabriella Moise, Silvia Marell, Mirella Furia, Maria Cristina Urbano, Roberta Carobbi, Simona Poleni, Hassan Kandil, Andrea Ballotta, Fabrizio Bettini, Manlio Sanseverino, Alessandro Gatta, Francesca Cecchini, Luca Guatteri, Gabriella Ciceri, Ferdinando Raimondi, Sandra Ferraris, Massimo Borelli, Valentina Bellato, Franco Cancellieri, Silvia Senni, Ester Bertocchi, Paola Ferri, Gianpietro Moioli, Alexandra Molin, Giovanni Salati, Pierpaolo Salsi, Emanuela Brunori, Daniele Elisei, Giuseppe Maggio, Federico Guardia Nicola, Marco Cavana, Giacomo Morelli, Arturo Guarino, Michele Isetta, Giorgio Tulli, Valerio Mangani, Nicola Rossi, Marta Ferrari, Francesco Bona, Monica Vay, Teresa Bartoli, Mauro Gallo, Katiuscia Vettoretto, Mauro Della Morte, Enrico Boselli, Daniela Puscio, Monia Bovo, Antonio Galzerano, Manuela Carli, Giovanni Zagara

Risultato della ricerca: Contributo in rivistaArticolo in rivista

35 Citazioni (Scopus)

Abstract

Background: The long pentraxin PTX3 is a key component of the humoral arm of innate immunity related to sepsis severity and mortality. We evaluated the clinical and prognostic significance of circulating PTX3 in the largest cohort ever reported of patients with severe sepsis or septic shock. Materials and methods: Plasma PTX3 was measured on days 1, 2 and 7 after randomization of 958 patients to albumin or crystalloids for fluid resuscitation in the multicentre Albumin Italian Outcome Sepsis (ALBIOS) trial. We tested the association of PTX3 and its changes over time with clinical severity, prevalent and incident organ dysfunctions, 90-day mortality and treatment. Results: PTX3 was high at baseline (72 [33–186] ng/mL) and rose with the severity and number of organ dysfunctions (P < 0·001) and the incidence of subsequent new failures. The PTX3 concentration dropped from day 1 to 7, but this decrease was less pronounced in patients with septic shock (P = 0·0004). Higher concentrations of PTX3 on day 1 predicted incident organ dysfunctions. Albumin supplementation was associated with lower levels of PTX3 in patients with septic shock (P = 0·005) but not in those without shock. In a fully adjusted multivariable model, PTX3 on day 7 predicted 90-day mortality. Smaller drops in PTX3 predicted higher 90-day mortality. Conclusions: In severe sepsis and septic shock, early high PTX3 predict subsequent new organ failures, while a smaller drop in circulating PTX3 over time predicts an increased risk of death. Patients with septic shock show lower levels of PTX3 when assigned to albumin than to crystalloids.
Lingua originaleEnglish
pagine (da-a)73-83
Numero di pagine11
RivistaEuropean Journal of Clinical Investigation
Volume47
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • Aged
  • Albumin
  • Albumins
  • Biochemistry
  • Biomarkers
  • C-Reactive Protein
  • Clinical Biochemistry
  • Crystalloid Solutions
  • Female
  • Fluid Therapy
  • Humans
  • Isotonic Solutions
  • Italy
  • Linear Models
  • Male
  • Middle Aged
  • Mortality
  • Multiple Organ Failure
  • Multivariate Analysis
  • Prognosis
  • Randomized Controlled Trials as Topic
  • Sepsis
  • Serum Amyloid P-Component
  • Severity of Illness Index
  • Shock, Septic
  • pentraxin 3
  • prognosis
  • septic shock
  • severe sepsis

Fingerprint Entra nei temi di ricerca di 'Pentraxin 3 in patients with severe sepsis or shock: the ALBIOS trial'. Insieme formano una fingerprint unica.

Cita questo