TY - JOUR
T1 - Pediatric tuberculosis in Italian children: Epidemiological and clinical data from the Italian register of pediatric tuberculosis
AU - Galli, Luisa
AU - Galli, Lavinia Maddalena
AU - Lancella, Laura
AU - Tersigni, Chiara
AU - Venturini, Elisabetta
AU - Venturini, Elena
AU - Chiappini, Elena
AU - Chiappini, Elisabetta
AU - Bergamini, Barbaramaria
AU - Codifava, Margherita
AU - Venturelli, Cristina
AU - Venturelli, Chiara
AU - Tosetti, Giulia
AU - Tosetti, Giovanni
AU - Marabotto, Caterina
AU - Cursi, Laura
AU - Boccuzzi, Elena
AU - Garazzino, Silvia
AU - Tovo, Pierangelo
AU - Pinon, Michele
AU - Serre, Danielele
AU - Castiglioni, Laura
AU - Vecchio, Andrealo
AU - Guarino, Alfredo
AU - Bruzzese, Eugenia
AU - Losurdo, Giuseppe
AU - Castagnola, Elio
AU - Bossi, Grazia
AU - Bossi, Giuliana
AU - Marseglia, Gianluigi
AU - Esposito, Susanna
AU - Bosis, Samantha
AU - Grandolfo, Rita
AU - Fiorito, Valentina
AU - Valentini, Piero
AU - Buonsenso, Danilo
AU - Domenici, Raffaele
AU - Montesanti, Marco
AU - Salvini, Filippomaria
AU - Riva, Enrica
AU - Dodi, Icilio
AU - Maschio, Francesca
AU - Abbagnato, Luisa
AU - Fiumana, Elisa
AU - Fornabaio, Chiara
AU - Ballista, Patrizia
AU - Portelli, Vincenzo
AU - Bottone, Gabriella
AU - Palladino, Nicola
AU - Valenzise, Mariella
AU - Vecchi, Barbara
AU - Gangi, Mariadi
AU - Lupi, Carla
AU - Villani, Alberto
AU - Villani, Andrea
AU - De Martino, Maurizio
PY - 2016
Y1 - 2016
N2 - Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, and public health centers in Italy using a standardized form, covering the period of time between 1 January 2010 and 31 December 2012. Children with active TB, latent TB, and those recently exposed to TB or recently adopted/immigrated from a high TB incidence country were enrolled. Overall, 4234 children were included; 554 (13.1%) children had active TB, 594 (14.0%) latent TB and 3086 (72.9%) were uninfected. Among children with active TB, 481 (86.8%) patients had pulmonary TB. The treatment of active TB cases was known for 96.4% (n = 534) of the cases. Overall, 210 (39.3%) out of these 534 children were treated with three and 216 (40.4%) with four first-line drugs. Second-line drugs where used in 87 (16.3%) children with active TB. Drug-resistant strains of Mycobacterium tuberculosis were reported in 39 (7%) children. Improving the surveillance of childhood TB is important for public health care workers and pediatricians. A non-negligible proportion of children had drug-resistant TB and was treated with second-line drugs, most of which are off-label in the pediatric age. Future efforts should concentrate on improving active surveillance, diagnostic tools, and the availability of antitubercular pediatric formulations, also in low-endemic countries.
AB - Tuberculosis (TB) is one of the leading causes of death worldwide. Over the last decades, TB has also emerged in the pediatric population. Epidemiologic data of childhood TB are still limited and there is an urgent need of more data on very large cohorts. A multicenter study was conducted in 27 pediatric hospitals, pediatric wards, and public health centers in Italy using a standardized form, covering the period of time between 1 January 2010 and 31 December 2012. Children with active TB, latent TB, and those recently exposed to TB or recently adopted/immigrated from a high TB incidence country were enrolled. Overall, 4234 children were included; 554 (13.1%) children had active TB, 594 (14.0%) latent TB and 3086 (72.9%) were uninfected. Among children with active TB, 481 (86.8%) patients had pulmonary TB. The treatment of active TB cases was known for 96.4% (n = 534) of the cases. Overall, 210 (39.3%) out of these 534 children were treated with three and 216 (40.4%) with four first-line drugs. Second-line drugs where used in 87 (16.3%) children with active TB. Drug-resistant strains of Mycobacterium tuberculosis were reported in 39 (7%) children. Improving the surveillance of childhood TB is important for public health care workers and pediatricians. A non-negligible proportion of children had drug-resistant TB and was treated with second-line drugs, most of which are off-label in the pediatric age. Future efforts should concentrate on improving active surveillance, diagnostic tools, and the availability of antitubercular pediatric formulations, also in low-endemic countries.
KW - Adolescent
KW - Ambulatory Care Facilities
KW - Antitubercular Agents
KW - Child
KW - Child, Preschool
KW - Children
KW - Female
KW - Hospitals, Pediatric
KW - Humans
KW - Infant
KW - Italian
KW - Italy
KW - Male
KW - Register
KW - Registries
KW - Tuberculosis
KW - Tuberculosis, Multidrug-Resistant
KW - Tuberculosis, Pulmonary
KW - Adolescent
KW - Ambulatory Care Facilities
KW - Antitubercular Agents
KW - Child
KW - Child, Preschool
KW - Children
KW - Female
KW - Hospitals, Pediatric
KW - Humans
KW - Infant
KW - Italian
KW - Italy
KW - Male
KW - Register
KW - Registries
KW - Tuberculosis
KW - Tuberculosis, Multidrug-Resistant
KW - Tuberculosis, Pulmonary
UR - http://hdl.handle.net/10807/171765
U2 - 10.3390/ijms17060960
DO - 10.3390/ijms17060960
M3 - Article
SN - 1661-6596
VL - 17
SP - N/A-N/A
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
ER -