TY - JOUR
T1 - Pediatric low-grade glioma and neurofibromatosis type 1: A single-institution experience
AU - Ruggiero, Antonio
AU - Attinà, Giorgio
AU - Campanelli, Anastasia
AU - Maurizi, Palma
AU - Triarico, Silvia
AU - Romano, Alberto
AU - Massimi, Luca
AU - Tamburrini, Gianpiero
AU - Verdolotti, Tommaso
AU - Mastrangelo, Stefano
PY - 2023
Y1 - 2023
N2 - Background:
Neurofibromatosis type 1 (NF1)-related gliomas appear to have a clinical behavior different from that of sporadic cases. The purpose of the study was to investigate the role of different factors in influencing the tumor response rate of children receiving chemotherapy for their symptomatic glioma.
Methods:
Between 1995 and 2015, 60 patients with low-grade glioma (42 sporadic cases and 18 cases with NF1) were treated. Patients with brainstem gliomas were excluded. Thirty-nine patients underwent exclusive or postsurgical chemotherapy (vincristine/carboplatin-based regimen).
Results:
Disease reduction was achieved in 12 of the 28 patients (42.8%) with sporadic low-grade glioma and in 9 of the 11 patients (81.8%) with NF1, with a significant difference between the 2 groups (P < 0.05). The response to chemotherapy in both the patient groups was not significantly influenced by sex, age, tumor site, and histopathology, although disease reduction occurred more frequently in children aged under 3 years.
Conclusions:
Our study showed that pediatric patients with low-grade glioma and NF1 are more likely to respond to chemotherapy than those with non-NF1.
AB - Background:
Neurofibromatosis type 1 (NF1)-related gliomas appear to have a clinical behavior different from that of sporadic cases. The purpose of the study was to investigate the role of different factors in influencing the tumor response rate of children receiving chemotherapy for their symptomatic glioma.
Methods:
Between 1995 and 2015, 60 patients with low-grade glioma (42 sporadic cases and 18 cases with NF1) were treated. Patients with brainstem gliomas were excluded. Thirty-nine patients underwent exclusive or postsurgical chemotherapy (vincristine/carboplatin-based regimen).
Results:
Disease reduction was achieved in 12 of the 28 patients (42.8%) with sporadic low-grade glioma and in 9 of the 11 patients (81.8%) with NF1, with a significant difference between the 2 groups (P < 0.05). The response to chemotherapy in both the patient groups was not significantly influenced by sex, age, tumor site, and histopathology, although disease reduction occurred more frequently in children aged under 3 years.
Conclusions:
Our study showed that pediatric patients with low-grade glioma and NF1 are more likely to respond to chemotherapy than those with non-NF1.
KW - Carboplatin
KW - Chemotherapy
KW - Children
KW - Glioma
KW - Neurofibromatosis type 1
KW - Outcome
KW - Carboplatin
KW - Chemotherapy
KW - Children
KW - Glioma
KW - Neurofibromatosis type 1
KW - Outcome
UR - http://hdl.handle.net/10807/237095
U2 - 10.4103/jcrt.jcrt_1677_21
DO - 10.4103/jcrt.jcrt_1677_21
M3 - Article
SN - 0973-1482
VL - 19
SP - 228
EP - 234
JO - Journal of Cancer Research and Therapeutics
JF - Journal of Cancer Research and Therapeutics
ER -