Pediatric Inflammatory Multisystem Syndrome Temporally Related With SARS-CoV-2: Immunological Similarities With Acute Rheumatic Fever and Toxic Shock Syndrome

Danilo Buonsenso, Francesca Riitano, Piero Valentini

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

Abstract

Several studies demonstrated that COVID-19 in children is a relatively mild disease. However, recently a more serious condition characterized by systemic inflammation with clinical or microbiological evidence of exposure to SARS-CoV-2 has been described. This syndrome is now known as either "Pediatric Inflammatory Multisystem Syndrome temporally related with COVID-19" (PIMS-TS) (1), or Multisystem Inflammatory Syndrome in Children (MIS-C) (2) and is currently considered a rare post-COVID-19 complication which, in a minority of cases, can lead to death. The signs and symptoms of PIMS-TS are largely overlapping with the for Kawasaki disease (KD) and toxic shock syndrome (TSS) and are characterized, by fever, systemic inflammation, abdominal pain and cardiac involvement. In this study, we describe clinical and immunological characteristics shared by PIMS-TS, acute rheumatic fever and TSS, in order to provide hypotheses to direct future clinical and basic research studies.
Lingua originaleEnglish
pagine (da-a)1-5
Numero di pagine5
RivistaFrontiers in Pediatrics
Volume8
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • COVID-19
  • MIS-C
  • toxic shock syndrome
  • SARS-CoV-2
  • acute rheumatic fever
  • PIMS-TS

Fingerprint

Entra nei temi di ricerca di 'Pediatric Inflammatory Multisystem Syndrome Temporally Related With SARS-CoV-2: Immunological Similarities With Acute Rheumatic Fever and Toxic Shock Syndrome'. Insieme formano una fingerprint unica.

Cita questo