TY - JOUR
T1 - PDGF receptor alpha inhibition induces apoptosis in glioblastoma cancer stem cells refractory to anti-Notch and anti-EGFR treatment
AU - Cenciarelli, Carlo
AU - Marei, Hany E.S.
AU - Zonfrillo, Manuela
AU - Pierimarchi, Pasquale
AU - Paldino, Emanuela
AU - Casalbore, Patrizia
AU - Felsani, Armando
AU - Vescovi, Angelo Luigi
AU - Maira, Giulio
AU - Mangiola, Annunziato
PY - 2014
Y1 - 2014
N2 - Cancer stem cells (CSC) represent a rare fraction of cancer cells characterized by resistance to chemotherapy and radiation, therefore nowadays there is great need to develop new targeted therapies for brain tumors and our study aim to target pivotal transmembrane receptors such as Notch, EGFR and PDGFR, which are already under investigation in clinical trials setting for the treatment of Glioblastoma Multiforme (GBM).
AB - Cancer stem cells (CSC) represent a rare fraction of cancer cells characterized by resistance to chemotherapy and radiation, therefore nowadays there is great need to develop new targeted therapies for brain tumors and our study aim to target pivotal transmembrane receptors such as Notch, EGFR and PDGFR, which are already under investigation in clinical trials setting for the treatment of Glioblastoma Multiforme (GBM).
KW - GBM, Cancer Stem Cells
KW - GBM, Cancer Stem Cells
UR - http://hdl.handle.net/10807/65970
U2 - 10.1186/1476-4598-13-247
DO - 10.1186/1476-4598-13-247
M3 - Article
SN - 1476-4598
VL - 13
SP - 247-N/A
JO - Molecular Cancer
JF - Molecular Cancer
ER -
