Pd-catalyzed intramolecular C-H activation for the synthesis of fused-1,2,3-triazole quinolines and dihydroquinolines

A Pd-catalyzed, simple, and efficient approach toward structurally diverse fused polycyclic [1,2,3]triazolo[4,5-c]quinoline and 4,5-dihydro-[1,2,3]triazolo[4,5-c]quinoline has been developed. The method is based on intramolecular Pd-catalyzed C-H activation and features operational simplicity, high atom economy, broad substrate scope, excellent yields, and good functional group tolerance. Gram-scale experiments and post-synthetic modifications were performed to extend the synthetic applicability of the proposed methodology and enhance the structural complexity of the obtained derivatives.