TY - JOUR
T1 - Patterns of cerebellar gray matter atrophy across Alzheimer’s disease progression
AU - Toniolo, S.
AU - Serra, L.
AU - Olivito, G.
AU - Marra, Camillo
AU - Bozzali, M.
AU - Cercignani, M.
PY - 2018
Y1 - 2018
N2 - The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer’s disease (AD). In the present work we used SUIT-VBM (spatially unbiased infratentorial template, voxel-based morphometry) to perform an analysis of the pattern of cerebellar gray matter (GM) atrophy in amnestic mild cognitive impairment (a-MCI) and AD dementia patients compared to healthy subjects (HS), in order to follow the changes of non-motor features of cerebellar degeneration throughout disease progression. This template has been validated to guarantee a significant improvement in voxel-to-voxel alignment of the individual fissures and the deep cerebellar nuclei compared to Montreal Neurological Institute (MNI) whole-brain template. Our analysis shows a progression of cerebellar GM volume changes throughout a continuous spectrum from early to late clinical stages of AD. In particular vermis and paravermian areas of the anterior (I-V) and posterior (VI) lobes are involved since the a-MCI stage, with a later involvement of the hemispheric part of the posterior lobes (VI lobule) and Crus I in AD dementia patients only. These findings support the role of the cerebellum in higher-level functions, and whilst confirming previous data on the involvement of Crus I in AD dementia, provide new evidence of an involvement of the vermis in the early stages of the disease.
AB - The role of the cerebellum in cognitive function has been broadly investigated in the last decades from an anatomical, clinical, and functional point of view and new evidence points toward a significant contribution of the posterior lobes of the cerebellum in cognition in Alzheimer’s disease (AD). In the present work we used SUIT-VBM (spatially unbiased infratentorial template, voxel-based morphometry) to perform an analysis of the pattern of cerebellar gray matter (GM) atrophy in amnestic mild cognitive impairment (a-MCI) and AD dementia patients compared to healthy subjects (HS), in order to follow the changes of non-motor features of cerebellar degeneration throughout disease progression. This template has been validated to guarantee a significant improvement in voxel-to-voxel alignment of the individual fissures and the deep cerebellar nuclei compared to Montreal Neurological Institute (MNI) whole-brain template. Our analysis shows a progression of cerebellar GM volume changes throughout a continuous spectrum from early to late clinical stages of AD. In particular vermis and paravermian areas of the anterior (I-V) and posterior (VI) lobes are involved since the a-MCI stage, with a later involvement of the hemispheric part of the posterior lobes (VI lobule) and Crus I in AD dementia patients only. These findings support the role of the cerebellum in higher-level functions, and whilst confirming previous data on the involvement of Crus I in AD dementia, provide new evidence of an involvement of the vermis in the early stages of the disease.
KW - Alzheimer’s disease
KW - Cerebellum
KW - Constructional apraxia
KW - Lobule VI
KW - Mild cognitive impairment
KW - SUIT
KW - Vermis
KW - Voxel-based morphometry
KW - Alzheimer’s disease
KW - Cerebellum
KW - Constructional apraxia
KW - Lobule VI
KW - Mild cognitive impairment
KW - SUIT
KW - Vermis
KW - Voxel-based morphometry
UR - https://publicatt.unicatt.it/handle/10807/206297
UR - https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85058955401&origin=inward
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85058955401&origin=inward
U2 - 10.3389/fncel.2018.00430
DO - 10.3389/fncel.2018.00430
M3 - Article
SN - 1662-5102
VL - 12
SP - N/A-N/A
JO - Frontiers in Cellular Neuroscience
JF - Frontiers in Cellular Neuroscience
IS - 20
ER -