Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

S Zanetti; Alessandra Bua; Giovanni Delogu; Cinzia Pusceddu; M Mura; F Saba; P Pirina; C Garzelli; C Vertuccio; La Sechi; Giovanni Fadda

doi:10.1128/CDLI.12.9.1135-1138.2005

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

S Zanetti, Alessandra Bua, Giovanni Delogu, Cinzia Pusceddu, M Mura, F Saba, P Pirina, C Garzelli, C Vertuccio, La Sechi, Giovanni Fadda

Risultato della ricerca: Contributo in rivista › Articolo in rivista › peer review

29 Citazioni (Scopus)

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

Lingua originale	English
pagine (da-a)	1135-1138
Numero di pagine	4
Rivista	Clinical and Diagnostic Laboratory Immunology
Volume	12
DOI	https://doi.org/10.1128/CDLI.12.9.1135-1138.2005
Stato di pubblicazione	Pubblicato - 2005

Keywords

Antibodies, Bacterial
Antibody Formation
Antibody Specificity
Antigens, Bacterial
Enzyme-Linked Immunosorbent Assay
Hemagglutinins
Humans
Lectins
Methylation
Mycobacterium tuberculosis
Recombinant Proteins
Tuberculosis, Pulmonary

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Zanetti, S., Bua, A., Delogu, G., Pusceddu, C., Mura, M., Saba, F., Pirina, P., Garzelli, C., Vertuccio, C., Sechi, L., & Fadda, G. (2005). Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin. Clinical and Diagnostic Laboratory Immunology, 12, 1135-1138. https://doi.org/10.1128/CDLI.12.9.1135-1138.2005

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title = "Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin",

abstract = "Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.",

keywords = "Antibodies, Bacterial, Antibody Formation, Antibody Specificity, Antigens, Bacterial, Enzyme-Linked Immunosorbent Assay, Hemagglutinins, Humans, Lectins, Methylation, Mycobacterium tuberculosis, Recombinant Proteins, Tuberculosis, Pulmonary, Antibodies, Bacterial, Antibody Formation, Antibody Specificity, Antigens, Bacterial, Enzyme-Linked Immunosorbent Assay, Hemagglutinins, Humans, Lectins, Methylation, Mycobacterium tuberculosis, Recombinant Proteins, Tuberculosis, Pulmonary",

author = "S Zanetti and Alessandra Bua and Giovanni Delogu and Cinzia Pusceddu and M Mura and F Saba and P Pirina and C Garzelli and C Vertuccio and La Sechi and Giovanni Fadda",

year = "2005",

doi = "10.1128/CDLI.12.9.1135-1138.2005",

language = "English",

volume = "12",

pages = "1135--1138",

journal = "Clinical and Diagnostic Laboratory Immunology",

issn = "1071-412X",

publisher = "American Society for Microbiology:PO Box 11127:Birmingham, AL 35201:(800)633-4931, (205)995-1567, EMAIL: asm.nonmembers.subs@ebsco.com, INTERNET: http://www.asm.org, Fax: (205)995-1588",

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Zanetti, S, Bua, A, Delogu, G, Pusceddu, C, Mura, M, Saba, F, Pirina, P, Garzelli, C, Vertuccio, C, Sechi, L & Fadda, G 2005, 'Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin', Clinical and Diagnostic Laboratory Immunology, vol. 12, pagg. 1135-1138. https://doi.org/10.1128/CDLI.12.9.1135-1138.2005

TY - JOUR

T1 - Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

AU - Zanetti, S

AU - Bua, Alessandra

AU - Delogu, Giovanni

AU - Pusceddu, Cinzia

AU - Mura, M

AU - Saba, F

AU - Pirina, P

AU - Garzelli, C

AU - Vertuccio, C

AU - Sechi, La

AU - Fadda, Giovanni

PY - 2005

Y1 - 2005

N2 - Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

AB - Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

KW - Antibodies, Bacterial

KW - Antibody Formation

KW - Antibody Specificity

KW - Antigens, Bacterial

KW - Enzyme-Linked Immunosorbent Assay

KW - Hemagglutinins

KW - Humans

KW - Lectins

KW - Methylation

KW - Mycobacterium tuberculosis

KW - Recombinant Proteins

KW - Tuberculosis, Pulmonary

KW - Antibodies, Bacterial

KW - Antibody Formation

KW - Antibody Specificity

KW - Antigens, Bacterial

KW - Enzyme-Linked Immunosorbent Assay

KW - Hemagglutinins

KW - Humans

KW - Lectins

KW - Methylation

KW - Mycobacterium tuberculosis

KW - Recombinant Proteins

KW - Tuberculosis, Pulmonary

UR - http://hdl.handle.net/10807/9225

U2 - 10.1128/CDLI.12.9.1135-1138.2005

DO - 10.1128/CDLI.12.9.1135-1138.2005

M3 - Article

SN - 1071-412X

VL - 12

SP - 1135

EP - 1138

JO - Clinical and Diagnostic Laboratory Immunology

JF - Clinical and Diagnostic Laboratory Immunology

ER -

Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Abstract

Keywords

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