Patients with pulmonary tuberculosis develop a strong humoral response against methylated heparin-binding hemagglutinin

Giovanni Delogu, Giovanni Fadda, Alessandra Bua, Cinzia Pusceddu, S Zanetti, M Mura, F Saba, P Pirina, C Garzelli, C Vertuccio, La Sechi

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

29 Citazioni (Scopus)

Abstract

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.
Lingua originaleEnglish
pagine (da-a)1135-1138
Numero di pagine4
RivistaClinical and Diagnostic Laboratory Immunology
Volume12
DOI
Stato di pubblicazionePubblicato - 2005

Keywords

  • Antibodies, Bacterial
  • Antibody Formation
  • Antibody Specificity
  • Antigens, Bacterial
  • Enzyme-Linked Immunosorbent Assay
  • Hemagglutinins
  • Humans
  • Lectins
  • Methylation
  • Mycobacterium tuberculosis
  • Recombinant Proteins
  • Tuberculosis, Pulmonary

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