Patient-Specific Modeling of Stented Coronary Arteries Reconstructed from Optical Coherence Tomography: Towards a Widespread Clinical Use of Fluid Dynamics Analyses

Francesco Burzotta, Claudio Chiastra, Susanna Migliori, Gabriele Dubini, Francesco Migliavacca

Risultato della ricerca: Contributo in rivistaArticolo in rivista

13 Citazioni (Scopus)

Abstract

The recent widespread application of optical coherence tomography (OCT) in interventional cardiology has improved patient-specific modeling of stented coronary arteries for the investigation of local hemodynamics. In this review, the workflow for the creation of fluid dynamics models of stented coronary arteries from OCT images is presented. The algorithms for lumen contours and stent strut detection from OCT as well as the reconstruction methods of stented geometries are discussed. Furthermore, the state of the art of studies that investigate the hemodynamics of OCT-based stented coronary artery geometries is reported. Although those studies analyzed few patient-specific cases, the application of the current reconstruction methods of stented geometries to large populations is possible. However, the improvement of these methods and the reduction of the time needed for the entire modeling process are crucial for a widespread clinical use of the OCT-based models and future in silico clinical trials.
Lingua originaleEnglish
pagine (da-a)1-17
Numero di pagine17
RivistaJournal of Cardiovascular Translational Research
DOI
Stato di pubblicazionePubblicato - 2017

Keywords

  • 3003
  • Cardiology and Cardiovascular Medicine
  • Computational fluid dynamics
  • Computer simulations
  • Coronary artery
  • Genetics
  • Genetics (clinical)
  • Image processing
  • Image segmentation
  • In silico clinical trial
  • Molecular Medicine
  • Optical coherence tomography
  • Stent

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