Pathophysiologic correlates of hypocholesterolemia in critically ill surgical patients

Felice Giuliante, Maria Vellone, Gennaro Nuzzo, Ivo Giovannini, Giuseppe Boldrini, Carlo Chiarla

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

55 Citazioni (Scopus)

Abstract

OBJECTIVE: To assess correlates of hypocholesterolemia in moderate to critical surgical illness. DESIGN: Prospective analysis of laboratory and clinical data. SETTING: Department of surgery in a university hospital. PATIENTS: 135 patients undergoing uncomplicated abdominal surgery or with sepsis, liver failure, hemorrhage, severe cholestasis, or multiple organ dysfunction syndrome (MODS). INTERVENTIONS: Surgical and/or medical therapy according to clinical status. MEASUREMENTS AND MAIN RESULTS: Determinations of total cholesterol, additional variables, and clinical data. Cholesterol decreased after surgery, in sepsis, liver failure, acute hemorrhage, and MODS and increased in cholestasis. Hypocholesterolemia correlated with decreases in plasma proteins and indices of hepatic protein synthetic adequacy, with hemodilution from blood loss, and was moderated or prevented by cholestasis. CONCLUSIONS: These results help to explain the dynamics of the development, clinical relevance, and negative prognostic value of hypocholesterolemia in critical illness.
Lingua originaleEnglish
pagine (da-a)748-751
Numero di pagine4
RivistaIntensive Care Medicine
Volume25
Stato di pubblicazionePubblicato - 1999

Keywords

  • Critical illness
  • Hypocholesterolemia
  • Liver insufficiency
  • Pathophysiology
  • Sepsis
  • Surgery

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