Pathological Gambling in Parkinson's disease: autonomic measures supporting impaired decision-making

Michela Balconi, Laura Angioletti, Chiara Siri, Nicoletta Meucci, Gianni Pezzoli

Risultato della ricerca: Contributo in rivistaArticolo in rivistapeer review

5 Citazioni (Scopus)

Abstract

According to the somatic marker hypothesis, autonomic measures and arousal modulation can reveal a difference in subgroups of patients developing impaired decision-making because of addictions. Previously, pathological gambling (PG) and Parkinson's disease (PD) have been associated with differential arousal levels during gambling behavior. However, no research considered the specific autonomic responses of Parkinson's disease patients with pathological gambling and with a previous history of gambling. Thus, this study investigated skin conductance responses (SCRs), skin conductance level (SCL) and heart rate (HR) during the Iowa Gambling Task (IGT) in two groups of PD patients with gambling disorder, active (PD Gamblers; n = 14) or remitted (PD Non-Gamblers; n = 13) and a control group of patients with Parkinson's disease only (n = 13). Anticipatory autonomic responses to disadvantageous decks and advantageous decks during the Iowa Gambling Task were measured for each participant. The PD Gamblers group performed worse than the PD Non-Gamblers and the control groups at the IGT task and exhibited lower SCRs, SCL, and HR during the decision-making processing of cards belonging to disadvantageous decks. The role of autonomic and behavioral measures was considered.
Lingua originaleEnglish
pagine (da-a)2392-2400
Numero di pagine9
RivistaEuropean Journal of Neuroscience
Volume50
DOI
Stato di pubblicazionePubblicato - 2019

Keywords

  • Iowa Gambling Task
  • Parkinson's disease
  • autonomic measures
  • behavioral addiction
  • pathological gambling
  • somatic marker hypothesis

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