TY - JOUR
T1 - Pathogenetic, clinical and pharmaco-economic assessment in rheumatoid arthritis (RA)
AU - Ferraccioli, Gianfranco
AU - Gremese, Elisa
PY - 2011
Y1 - 2011
N2 - Rheumatoid arthritis (RA) has become one of the most studied autoimmune chronic inflammatory diseases (ACIDs), either from the pathogenetic or from the therapeutic point of view. It is recognized that synovial fibroblasts, TH1 and TH17 cells likely play along with the B cells the most relevant role. The disease has a polygenic background that characterizes the seropositive and the seronegative subsets. Over the years, we realized that no more than 15-20% of long-standing RA (LSRA) treated with conventional drugs can reach full remission, whereas the most recent data in early RA (ERA) have demonstrated that 40-60% can be put into clinical and biological remission. This of course is of crucial importance to avoid any progression of the structural damage that leads to functional disability. If we consider that a disability index score (Health Assessment Questionnaire 0-3) of a severe arthritis can cost up to 21,000 EUs, while a mild disease will cost not more than 5,500 EUs per year, it appears very clear that a low disease activity (LDA) or a remission state (Rem) should be the aim in each single patient, in order to keep the workability and maintain the productivity. This is and should be the major aim in each RA patient.
AB - Rheumatoid arthritis (RA) has become one of the most studied autoimmune chronic inflammatory diseases (ACIDs), either from the pathogenetic or from the therapeutic point of view. It is recognized that synovial fibroblasts, TH1 and TH17 cells likely play along with the B cells the most relevant role. The disease has a polygenic background that characterizes the seropositive and the seronegative subsets. Over the years, we realized that no more than 15-20% of long-standing RA (LSRA) treated with conventional drugs can reach full remission, whereas the most recent data in early RA (ERA) have demonstrated that 40-60% can be put into clinical and biological remission. This of course is of crucial importance to avoid any progression of the structural damage that leads to functional disability. If we consider that a disability index score (Health Assessment Questionnaire 0-3) of a severe arthritis can cost up to 21,000 EUs, while a mild disease will cost not more than 5,500 EUs per year, it appears very clear that a low disease activity (LDA) or a remission state (Rem) should be the aim in each single patient, in order to keep the workability and maintain the productivity. This is and should be the major aim in each RA patient.
KW - Arthritis, Rheumatoid
KW - Cost Savings
KW - Economics, Pharmaceutical
KW - Humans
KW - Questionnaires
KW - Arthritis, Rheumatoid
KW - Cost Savings
KW - Economics, Pharmaceutical
KW - Humans
KW - Questionnaires
UR - http://hdl.handle.net/10807/3404
U2 - 10.1007/s11739-011-0668-6
DO - 10.1007/s11739-011-0668-6
M3 - Article
SN - 1970-9366
VL - 6 Suppl 1
SP - 11
EP - 15
JO - INTERNAL AND EMERGENCY MEDICINE
JF - INTERNAL AND EMERGENCY MEDICINE
ER -