Past and future of the molecular characterization of the T cell repertoire: Some highlights of eli sercarz’s contributions

Gabriele Di Sante, Francesco Ria, Maria Tredicine, Antonella Di Pino, Simona Rolla

Risultato della ricerca: Contributo in rivistaArticolo in rivista

1 Citazioni (Scopus)

Abstract

The contribution of Eli E. Sercarz to immunology and immunopathology has been remarkable and achieved many milestones in the understanding of the processes of the mechanisms fine-tuning immune responses. A part of his work was dedicated to the study of the deep complexity of the lymphocyte T cell repertoire and its importance during the physiologic development and disease, such as clonal heterogeneity of T cell responses. Starting from these studies, under his mentoring, we had the opportunity to implement the spectratyping method and apply it to human and experimental autoimmune diseases, obtaining intriguing results. The open question of this brief review is the possible role of this fine and complex technique, the immunoscope analysis, in the era of the big data and omics.
Lingua originaleEnglish
pagine (da-a)249-253
Numero di pagine5
RivistaCritical Reviews in Immunology
Volume40
DOI
Stato di pubblicazionePubblicato - 2020

Keywords

  • Antigen specificity
  • Immunoscope
  • T cell receptor
  • Repertoire
  • Spectratyping
  • Next-generation sequencing

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