Background: In many primary tumors, parathyroid hormone-related peptide (PTHrP) and PTHrP
type 1 receptor (PTH1R) are coexpressed, supporting the possibility that PTHrP/PTH1R system
can mediate important signals for tumor progression through paracrine/autocrine mechanisms.
In non-small cell lung carcinoma the clinical relevance of the expression of PTH1R remains to be
Methods: Fifty-four lung adenocarcinomas of mixed histologic type from patients with stage I and
II cancer were assayed by quantitative immunohistochemistry for the expression of PTHrP and
Results: PTHrP and PTH1R were expressed in a wide range of intensity in the cytoplasm of tumor
cells, and their values showed a positive correlation. PTH1R, but not PTHrP, was expressed
by plasma cells infi ltrating the tumor stroma. PTHrP and PTH1R were not associated with age,
tumor diameter, or histopathologic grading, whereas they were directly associated with lymph
node involvement at presentation. Cox regression analysis, using PTHrP and PTH1R as continuous
covariates, showed that the covariate levels were directly associated with the risk of death and
metastasis. Patients whose tumors coexpressed high levels of PTHrP and PTH1R showed the
highest risk of metastasis (relative risk, 5.89; 95% CI, 2.1-16.6; P 5 .0003) and death (relative risk,
6.24; 95% CI, 1.6-23.9; P 5 .0033). The presence of PTH1R-positive plasma cells in the tumor
stroma was associated with a more favorable survival rate independently from the PTHrP status
of the tumor.
Conclusion: The paracrine/autocrine signaling through PTHrP/PTH1R could be important in
early-stage lung adenocarcinoma progression.
|Numero di pagine||11|
|Stato di pubblicazione||Pubblicato - 2010|