Palladium-catalyzed nucleophilic substitution of propargylic carbonates and meldrum's acid derivatives

The palladium-catalyzed reaction of propargylic carbonates with Meldrum's acid derivatives proceeds smoothly in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give substitution products. The substitution products can be useful intermediates for the stereoselective synthesis of functionalized (Z)-γ-alkylidene-γ-butyrolactones. Propargylic carbonates react with Meldrum's acid derivatives in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give propargylic substitution products.