TY - JOUR
T1 - Palladium-catalyzed nucleophilic substitution of propargylic carbonates and meldrum's acid derivatives
AU - Ambrogio, Ilaria
AU - Cacchi, Sandro
AU - Fabrizi, Giancarlo
AU - Goggiamani, Antonella
AU - Iazzetti, Antonia
PY - 2015
Y1 - 2015
N2 - The palladium-catalyzed reaction of propargylic carbonates with Meldrum's acid derivatives proceeds smoothly in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give substitution products. The substitution products can be useful intermediates for the stereoselective synthesis of functionalized (Z)-γ-alkylidene-γ-butyrolactones. Propargylic carbonates react with Meldrum's acid derivatives in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give propargylic substitution products.
AB - The palladium-catalyzed reaction of propargylic carbonates with Meldrum's acid derivatives proceeds smoothly in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give substitution products. The substitution products can be useful intermediates for the stereoselective synthesis of functionalized (Z)-γ-alkylidene-γ-butyrolactones. Propargylic carbonates react with Meldrum's acid derivatives in the presence of Pd(OAc)2 and P(2-furyl)3 in THF at 80 °C to give propargylic substitution products.
KW - Alkynes
KW - Homogeneous catalysis
KW - Nucleophilic substitution
KW - Palladium
KW - Alkynes
KW - Homogeneous catalysis
KW - Nucleophilic substitution
KW - Palladium
UR - http://hdl.handle.net/10807/200524
U2 - 10.1002/ejoc.201500337
DO - 10.1002/ejoc.201500337
M3 - Article
SN - 1099-0690
VL - 2015
SP - 3147
EP - 3151
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
ER -