Palladium-Catalyzed Cascade Approach to 12-(Aryl)indolo[1,2- c ]quinazolin-6(5 H)-ones

Antonia Iazzetti, Antonio Arcadi, Sandro Cacchi, Giancarlo Fabrizi, Francesca Ghirga, Antonella Goggiamani, Fabio Marinelli

Risultato della ricerca: Contributo in rivistaArticolo in rivista

Abstract

A straightforward one-pot approach to the synthesis of challenging 12-arylindolo[1,2- c ]quinazolin-6(5 H)-ones is described. Starting from readily available o -(o -aminophenylethynyl)trifluoroacetanilides, palladium-catalyzed aminoarylation of the triple bond with ArI, ArBr, and ArN 2+ BF 4- is followed by cyclization of the resulting N -trifluoroacetyl-2-(o -aminophenyl)-3-aryl indole. This sequential reaction provides the title compounds by means of a rare elimination of trifluoromethane.
Lingua originaleEnglish
pagine (da-a)1133-1140
Numero di pagine8
RivistaSynthesis
Volume50
DOI
Stato di pubblicazionePubblicato - 2018

Keywords

  • elimination
  • indoles
  • palladium
  • polycycles
  • quinazolinones
  • trifluoromethane

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